From the FDA Drug Label
Ursodiol therapy has not been associated with liver damage. Abnormalities in liver enzymes have not been associated with Ursodiol therapy and, in fact, Ursodiol has been shown to decrease liver enzyme levels in liver disease.
Hepatosafe akt: Ursodiol is considered hepatosafe, as it has not been associated with liver damage and has been shown to decrease liver enzyme levels in liver disease 1.
- Key points:
- No association with liver damage
- Decreases liver enzyme levels in liver disease
- Patients should have liver enzymes measured at the initiation of therapy and thereafter as indicated by clinical circumstances
From the Research
Hepatosafe AKT should be used with caution and under the guidance of a healthcare provider, as the current evidence on its effectiveness for liver health support is limited and inconclusive. The supplement typically contains a combination of ingredients like milk thistle (silymarin), N-acetyl cysteine, and various vitamins and minerals that are claimed to support liver function and detoxification processes. According to a study published in 2018 2, milk thistle has been shown to have anti-inflammatory, immunomodulating, antifibrotic, antioxidant, and liver-regenerating properties, which may be beneficial for patients with liver diseases. However, a systematic review and meta-analysis published in 2007 3 found that milk thistle had no significant effect on mortality, complications of liver disease, or liver histology in patients with alcoholic and/or hepatitis B or C liver diseases.
Some key points to consider when using Hepatosafe AKT include:
- The standard dosage is usually 1-2 capsules daily with meals, but this may vary by manufacturer
- Dietary supplements are not regulated as strictly as medications, and their quality and efficacy can vary widely
- Patients with existing liver conditions, pregnant or breastfeeding women, or those taking other medications should consult with their healthcare provider before starting Hepatosafe AKT
- The supplement should complement, not replace, healthy lifestyle choices like limiting alcohol consumption, maintaining a balanced diet, and regular exercise for optimal liver health
It is also important to note that the evidence on the effectiveness of milk thistle for liver health support is not consistent across all studies. A study published in 2005 4 found that milk thistle had no significant effect on all-cause mortality, complications of liver disease, or liver histology, while a study published in 2002 5 found that milk thistle was safe and well-tolerated, but had no significant effect on mortality, histology, or biochemical markers of liver function. However, the most recent and highest-quality study on this topic, published in 2018 2, suggests that milk thistle may have potential benefits for patients with liver diseases, and therefore Hepatosafe AKT may be considered as a complementary therapy for liver health support, under the guidance of a healthcare provider.