From the Guidelines
Recommended Dosage of Vancomycin for Gram-positive Cocci
Vancomycin is typically administered at a dose of 15-20 mg/kg every 8-12 hours, with a maximum daily dose of 2 grams 1.
Key Considerations
- The recommended dosage for patients with normal renal function is 1 gram every 12 hours, with adjustments made for patients with impaired renal function 1.
- In cases of complicated skin and skin structure infections, a dose of 15-20 mg/kg every 8-12 hours is recommended, with treatment durations ranging from 7-14 days 1.
- Trough monitoring is recommended for serious infections and patients who are morbidly obese, have renal dysfunction, or have fluctuating volumes of distribution 1.
- Vancomycin trough concentrations of 15–20 lg/mL are recommended for serious infections, such as bacteremia, infective endocarditis, osteomyelitis, meningitis, pneumonia, and severe SSTI 1.
- Weight-based dosing is particularly important in obese patients, who are likely to be underdosed when conventional dosing strategies of 1 g every 12 h are used 1.
From the FDA Drug Label
DOSAGE AND ADMINISTRATION Infusion-related events are related to both the concentration and the rate of administration of vancomycin. Patients with Normal Renal Function Adults The usual daily intravenous dose is 2 g divided either as 500 mg every 6 hours or 1 g every 12 hours. Pediatric patients The usual intravenous dosage of vancomycin is 10 mg/kg per dose given every 6 hours. Neonates In pediatric patients up to the age of 1 month, the total daily intravenous dosage may be lower In neonates, an initial dose of 15 mg/kg is suggested, followed by 10 mg/kg every 12 hours for neonates in the 1st week of life and every 8 hours thereafter up to the age of 1 month.
The recommended dosage of Vancomycin for Gram-positive cocci is:
- Adults with normal renal function: 2 g daily, divided as 500 mg every 6 hours or 1 g every 12 hours
- Pediatric patients: 10 mg/kg every 6 hours
- Neonates: initial dose of 15 mg/kg, followed by 10 mg/kg every 12 hours for the first week of life and every 8 hours thereafter up to 1 month of age 2
From the Research
Vancomycin Dosage for Gram-positive Cocci
The recommended dosage of Vancomycin for Gram-positive cocci is not explicitly stated in the provided studies. However, some studies mention the dosage of Vancomycin in comparison to other antibiotics:
- A phase III trial compared ceftobiprole 500 mg with vancomycin 1 g, each administered twice daily for 7-14 days 3.
- Another phase III trial compared ceftobiprole 500 mg every 8 hours with vancomycin 1 g every 12 hours plus ceftazidime 1 g every 8 hours 3.
Key Points
- Vancomycin is used as a standard therapy for complicated skin and soft tissue infections caused by Gram-positive cocci 4, 5.
- The dosage of Vancomycin is not explicitly stated in the provided studies, but it is mentioned as a comparator in several trials 3.
- Daptomycin is another antibiotic used to treat Gram-positive cocci, and its dosage is mentioned in several studies 5, 6.
- The choice of antibiotic and dosage depends on the specific infection, patient population, and other factors, and should be guided by clinical guidelines and expert opinion.