From the Guidelines
Dosage Comparison
Trulicity (dulaglutide) pen is administered at a dose of 0.75 mg subcutaneously once weekly, which can be titrated to 1.5 mg once weekly for additional glycemic control 1, whereas semaglutide is administered at a dose of 0.25 mg subcutaneously once weekly, which can be increased to 0.5 mg and then to 1 mg once weekly for glycemic control 1.
- The recommended dosing for Trulicity is 0.75 mg or 1.5 mg subcutaneously once weekly 1.
- The recommended dosing for semaglutide is 0.25 mg, 0.5 mg, or 1 mg subcutaneously once weekly 1.
- It's worth noting that semaglutide also has an oral formulation, which is administered at a dose of 3 mg once daily, but this is not directly comparable to the subcutaneous formulation of Trulicity 1.
- The dosing regimens for both medications are designed to provide a sustained release of the active ingredient over a period of time, with Trulicity providing a 7-day release and semaglutide providing a weekly release 1.
- The 1 mg daily dose of semaglutide is not a standard dosing regimen for this medication, as it is typically administered once weekly for the treatment of type 2 diabetes 1.
From the Research
Dosage Comparison
- The dosage of Trulicity (dulaglutide) pen is 0.75 or 1.5 mg once weekly 2, 3.
- Semaglutide is available in different formulations, including a once-weekly subcutaneous injection and a daily oral preparation 4, 5, 6.
- The daily oral preparation of semaglutide is taken at a dose of 1 mg daily, but the study does not provide a direct comparison with the dulaglutide pen dosage 4.
- It is essential to note that the dosages of dulaglutide and semaglutide are not directly comparable due to their different formulations and administration routes.
Key Differences
- Dulaglutide is administered once weekly, while semaglutide has both once-weekly and daily oral formulations 2, 4, 3, 5, 6.
- The primary pharmacodynamic difference between short-acting and long-acting GLP-1 RAs, such as dulaglutide and semaglutide, is their effect on fasting glucose and postprandial glucose 5.