From the Guidelines
The recommended dosage of Trulicity (Dulaglutide) for weight loss is 0.75mg or 1.5mg administered via subcutaneous injection once weekly 1.
Key Points
- The dosage is initiated at 0.75mg once weekly, with the option to increase to 1.5mg if additional glycemic control is required or if the patient tolerates the initial dose 1.
- The treatment duration is individualized based on patient response and weight loss goals.
- It's essential to note that while the provided evidence does not explicitly state the use of Dulaglutide for weight loss, other GLP-1 RAs, such as Liraglutide and Semaglutide, have approved indications for weight management, with specific dosages for this purpose 1.
- However, based on the available information, the dosage of 0.75mg or 1.5mg once weekly is the recommended regimen for Dulaglutide, which may be considered for weight loss in certain patients, particularly those with type 2 diabetes or multiple cardiovascular risk factors 1.
From the FDA Drug Label
2 DOSAGE AND ADMINISTRATION
2.1 Adult Dosage The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. After 4 weeks, the dosage may be increased to 1.5 mg once weekly for additional glycemic control. If additional glycemic control is needed, increase the dosage in 1.5 mg increments after at least 4 weeks on the current dosage. The maximum recommended dosage is 4.5 mg injected subcutaneously once weekly.
The dosage of Trulicity (Dulaglutide) for weight loss is not explicitly stated in the label, but the recommended dosages for glycemic control are:
- Starting dosage: 0.75 mg once weekly
- Maximum dosage: 4.5 mg once weekly However, the label does not provide information on the dosage for weight loss specifically. 2
From the Research
Dosage of Trulicity (Dulaglutide) for Weight Loss
- The dosage of Trulicity (Dulaglutide) for weight loss is typically 1.5 mg once weekly, as seen in several studies 3, 4, 5.
- A study found that dulaglutide dosages >1 mg/day significantly decreased body weight (BW), body mass index (BMI), and waist circumference (WC) 3.
- Another study compared semaglutide with dulaglutide in patients with type 2 diabetes and found that dulaglutide 1.5 mg was effective in reducing body weight 4.
- A post-hoc analysis of the AWARD-4 study found that once-weekly dulaglutide 1.5 mg or 0.75 mg, plus insulin lispro, resulted in significant weight loss compared to insulin glargine plus insulin lispro 5.
- The efficacy of dulaglutide in reducing body weight has been demonstrated in various studies, with doses ranging from 0.75 mg to 1.5 mg once weekly 3, 4, 6, 5.
Key Findings
- Dulaglutide 1.5 mg once weekly has been shown to be effective in reducing body weight and improving glycemic control in patients with type 2 diabetes 3, 4, 5.
- The dose-response meta-analysis revealed that body weight decreased significantly when dulaglutide was prescribed in doses ≤3 mg/day versus >3 mg/day 3.
- Dulaglutide has been found to be effective in reducing body weight in patients with obesity, with a notable decrease in body weight compared to those without obesity 3.