From the Research
Secretin is released from S cells in the small intestine. The small intestine is the primary site of secretin release, and this hormone plays a crucial role in regulating various physiological processes, including pancreatic secretion, gastric acid secretion, and bile production 1. The S cells responsible for secretin release are found in the mucosa of the duodenum and jejunum, and they detect the low pH of acidic chyme from the stomach, responding by secreting secretin into the bloodstream.
Some of the key functions of secretin include:
- Stimulating the secretion of bicarbonate-rich pancreatic juice to neutralize acidic content in the duodenum
- Inhibiting gastric acid secretion and gastric emptying to slow the release of more acid into the duodenum
- Stimulating bile production by the liver and increasing bile flow from the gallbladder The distribution of S cells in the small intestine is significant, as they are concentrated in the proximal portions where acid neutralization is most critical for proper digestion and absorption of nutrients 2.
While there are various studies on secretin and its functions, the most relevant information comes from a study published in the Annals of Translational Medicine, which provides a comprehensive review of the multiple roles of secretin and its receptor in regulating epithelial functions in various organ systems 1. This study highlights the importance of secretin in maintaining proper digestive and absorptive processes, and its release from S cells in the small intestine is a critical component of this process.