What are the clinically proven benefits of taking 6000 milligrams of oil of oregano and black seed oil (Nigella sativa)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 29, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Oil of oregano and black seed oil have not been clinically proven at 6000 mg doses for any specific health condition, and such a high dosage is not supported by clinical evidence. While both oils have shown some antimicrobial, anti-inflammatory, and antioxidant properties in preliminary research, the 6000 mg dosage is extremely high and could potentially cause adverse effects including digestive upset, allergic reactions, or interactions with medications. For oil of oregano, typical supplemental doses range from 150-600 mg daily, as seen in a study where 600 mg emulsified oil of oregano daily led to the disappearance of certain enteric parasites 1. Black seed oil is commonly used at 1-2.5 grams daily. The active compounds in oregano oil (carvacrol and thymol) and black seed oil (thymoquinone) do have biological activity, but their therapeutic effects require more rigorous clinical trials to establish proper dosing, safety, and efficacy for specific conditions. A recent study highlighted the antimicrobial and antioxidant activity of oregano essential oil, with carvacrol being the main component 2. If you're considering using these supplements, it's advisable to start with much lower doses and consult with a healthcare provider, especially if you have underlying health conditions or take medications. Some studies have reviewed the beneficial effects of oregano essential oils on health, including their antioxidant, anti-inflammatory, antidiabetic, and cancer suppressor properties 3, and their potential use as food additives due to their antimicrobial and antioxidant activity 4. However, these findings do not support the use of 6000 mg doses.

Key points to consider:

  • Typical supplemental doses of oil of oregano range from 150-600 mg daily
  • Black seed oil is commonly used at 1-2.5 grams daily
  • The 6000 mg dosage is extremely high and not supported by clinical evidence
  • Potential adverse effects include digestive upset, allergic reactions, or interactions with medications
  • Consult with a healthcare provider before using these supplements, especially with underlying health conditions or medications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.