From the Research
Secretin is produced by S cells in the small intestine. The production of secretin is a critical component of the digestive process, and its role is multifaceted. According to a study published in the Annals of Translational Medicine in 2013 1, secretin affects the function of several organ systems. The S cells responsible for secreting secretin are located in the small intestine, and upon release, secretin influences various bodily functions, including the regulation of epithelial secretion in the pancreas and liver. Key functions of secretin include stimulating the pancreas to produce bicarbonate-rich pancreatic juice to neutralize stomach acid, inhibiting gastric acid secretion and gastric emptying, and promoting bile production and release. These actions collectively contribute to creating an optimal environment for digestion and nutrient absorption. The specific mechanisms and effects of secretin are complex, involving the interaction with its receptor, which is expressed in several cell types, as discussed in the study 1.
Some of the key points about secretin production and function include:
- Secretin is secreted by S cells in response to specific stimuli, such as acidic chyme entering the small intestine.
- It plays a crucial role in regulating the pH environment of the duodenum by stimulating the production of bicarbonate-rich pancreatic juice.
- Secretin has trophic effects on several cell types and is involved in the regulation of epithelial functions in various organ systems, as highlighted in the study 1.
- Its receptors are expressed in the basolateral domain of several cell types, facilitating its wide range of effects on the body.
Overall, the production of secretin by S cells in the small intestine is a vital aspect of digestive physiology, and understanding its functions and mechanisms of action can provide insights into both normal digestive processes and the pathogenesis of digestive disorders.