What is the procedure for performing arthrocentesis (joint drainage) of the knee?

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From the Guidelines

Knee drainage, or arthrocentesis, should be performed under sterile conditions with a 18-22 gauge needle attached to a syringe, typically from the lateral approach with the knee flexed at 15-20 degrees, and fluid analysis should include a total cell count and differential leukocyte count, as well as culture for aerobic and anaerobic organisms 1.

Procedure Details

The procedure involves inserting a needle into the knee joint to remove excess fluid for diagnostic or therapeutic purposes.

  • First, the skin over the knee is cleaned with an antiseptic solution like chlorhexidine or povidone-iodine.
  • Local anesthesia (typically 1-2% lidocaine) is injected into the skin and subcutaneous tissues.
  • Using sterile technique, a needle attached to a syringe is inserted into the joint space.
  • The fluid is aspirated slowly and collected for analysis if needed.
  • After removing the needle, pressure is applied to the site, and a sterile bandage is placed.

Post-Procedure Care

Post-procedure, patients should rest the knee for 12-24 hours and watch for signs of infection like increased pain, redness, or fever.

  • This procedure relieves pressure from accumulated fluid, reduces pain, and allows for diagnostic testing of the fluid to identify conditions like infection, gout, or inflammatory arthritis.
  • Complications may include infection, bleeding, or pain, which is why proper sterile technique is essential, as supported by the Infectious Diseases Society of America guidelines 1.

Diagnostic Considerations

The synovial fluid analysis should include a total cell count and differential leukocyte count, as well as culture for aerobic and anaerobic organisms, and a crystal analysis can also be performed if clinically indicated 1.

  • The American College of Radiology suggests that knee joint aspiration, often with fluoroscopy or ultrasound guidance, is extremely useful in diagnosing joint infection after total knee arthroplasty 1.

From the Research

Knee Drainage Procedure

To perform a knee drainage, also known as arthrocentesis, the following steps can be considered:

  • The procedure is typically performed to collect fluid from the joint for analysis or to inject medication for pain relief 2, 3
  • It is essential to follow proper technique and precautions to minimize the risk of complications, such as bleeding or infection 4, 5
  • The safety of the procedure has been established in patients receiving anticoagulation therapy, including those on direct oral anticoagulants (DOACs) 4 and warfarin 5

Precautions and Considerations

  • Patients on anticoagulation therapy can undergo arthrocentesis and joint injection without discontinuing their medication, as the risk of bleeding is low 4, 5
  • The procedure can be performed in an outpatient setting, and patients can be monitored for any potential complications 4
  • Exercise and physical therapy may be recommended after the procedure to improve range of motion and reduce pain, although the evidence is limited to temporomandibular joint arthrocentesis 6

Key Points to Consider

  • Arthrocentesis is a safe and useful procedure for diagnostic and therapeutic purposes 2, 3
  • The procedure can provide significant pain relief and improve joint function 2, 3
  • Proper technique and precautions are essential to minimize the risk of complications 4, 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Arthrocentesis: the latest on joint pain relief.

The Nurse practitioner, 2013

Research

The Effect of Exercise on Range of Movement and Pain After Temporomandibular Joint Arthrocentesis.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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