From the FDA Drug Label
Clindamycin is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Clindamycin is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylocci Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of colitis, as described in the BOXED WARNING, before selecting clindamycin, the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin)
For a pregnant patient with dental caries who is allergic to Augmentin (amoxicillin-clavulanate), Clindamycin may be considered as an alternative antibiotic option, as it can be used in penicillin-allergic patients 1. However, the decision to use clindamycin should be made with caution, taking into account the risk of colitis and considering less toxic alternatives.
- The patient's specific condition and the causative organisms of the infection should be evaluated through bacteriologic studies to determine the suitability of clindamycin.
- It is essential to weigh the benefits and risks of using clindamycin in pregnant patients and consider alternative treatments when possible.
From the Research
Antibiotic Recommendations for Pregnant Patients with Dental Caries
- For a pregnant patient with dental caries who is allergic to Augmentin (amoxicillin-clavulanate), alternative antibiotics can be considered 2, 3.
- According to the study published in 2009, macrolide antibiotics such as erythromycin can be used in patients allergic to penicillin 2.
- Another study published in 1994 found that azithromycin is a safe alternative for patients allergic to penicillin and/or cephalosporin 3.
- It is essential to note that the use of antibiotics during pregnancy should be carefully evaluated, as maternal antibiotic exposure may increase the risk of childhood allergic diseases 4.
- The decision to administer a specific antibiotic requires that the benefits outweigh the potential risks of the drug therapy 5.
Considerations for Antibiotic Use in Pregnancy
- The study published in 2021 highlights the importance of penicillin allergy assessment in pregnancy, as it can impact antibiotic use and reduce the risk of broad-spectrum antibiotic use 6.
- Antibiotic regimens for pregnant patients with dental caries should be selected based on their safety and effectiveness, taking into account the potential risks to the mother and fetus 2, 5.