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From the Research
Medications for Diastolic Dysfunction
The following medications have been studied for their effectiveness in treating diastolic dysfunction:
- Angiotensin converting enzyme inhibitors and angiotensin receptor blockers, which have been shown to be effective in improving measures of diastolic function 1
- Beta-blockers, which can improve left ventricular diastolic and long axis function when a significant heart rate reduction is achieved 2
- Calcium channel blockers, which have shown some efficacy in improving indices of diastolic filling 1
- Diuretics, which are recommended for symptomatic patients with heart failure and preserved left ventricular systolic function 3
- Non-dihydropyridine calcium channel blockers, which are specified by the European Society of Cardiology as a type of therapy in diastolic heart failure 4
Study Findings
Several studies have investigated the effects of these medications on diastolic dysfunction:
- The Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) study and the Candesartan in Heart Failure: Assessment in Reduction of Mortality and Morbidity (CHARM-Preserved) trial failed to show improved morbidity and mortality with angiotensin receptor blockers 1
- The Losartan Intervention For End-point Reduction in Hypertension (LIFE) Study showed reduced heart failure hospitalization in hypertensive patients with normal in-treatment diastolic function 1
- A study on the effects of beta blockers on left ventricular diastolic function found that optimal heart rate reduction is important for improving diastolic function 2
- A randomized prospective controlled study found that enalapril, bisoprolol, carvedilol, and irbesartan had different effects on parameters of diastolic function in patients with chronic heart failure 5