Does Xeloda (capecitabine) cause dysphagia?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 30, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the FDA Drug Label

Gastrointestinal: ... dysphagia ... The FDA drug label mentions dysphagia as a clinically relevant adverse event in <5% of patients, which is related to difficulty swallowing.

  • Dysphagia was reported in patients treated with XELODA monotherapy. 1

From the Research

If you're experiencing difficulty swallowing Xeloda (capecitabine), contact your healthcare provider immediately as this could be a serious issue, and they may consider alternative administration methods or supportive care as suggested by recent studies 2. When experiencing difficulty swallowing Xeloda, it's crucial to address the issue promptly to prevent complications and ensure the effectiveness of the medication.

Key Considerations

  • Xeloda tablets should be swallowed whole with water within 30 minutes after a meal.
  • If swallowing is difficult, ask your doctor about temporarily crushing the tablets or mixing them with water, though this isn't typically recommended without professional guidance.
  • Never break or cut the tablets yourself as this can affect the medication's effectiveness and safety.
  • Swallowing difficulties might be due to mucositis or esophagitis, which are potential side effects of Xeloda, as discussed in the context of managing medication-related dysphagia 3.

Management and Supportive Care

  • Your doctor might recommend temporary dose reduction, treatment interruption, or supportive care with pain relievers or oral rinses to manage symptoms.
  • Staying well-hydrated and eating soft foods can help manage these symptoms, aligning with principles for managing dysphagia in various patient populations, including those with head and neck cancer 4, 5.
  • If swallowing problems persist or worsen, your oncologist might need to consider alternative treatment options or administration methods to ensure you receive proper cancer treatment while maintaining your comfort and safety, reflecting the importance of personalized care plans in dysphagia management 6.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.