From the Research
The maximum daily dose of vitamin D for adults is 7000 IU, as recommended for patients with increased risk of vitamin D deficiency, including those with obesity, liver disease, or malabsorption syndromes, according to the most recent study 1. This dose is considered safe and effective for maintaining 25(OH)D concentrations of at least 30 ng/mL in high-risk patients.
- The study suggests that daily doses of 7000 IU or intermittent doses of 30,000 IU/week should be considered for a prolonged time as prophylactic or maintenance doses, mainly in obese patients, patients with liver disease, and patients with malabsorption syndromes.
- For the treatment of possible vitamin D deficiency without assessment of 25(OH)D in these groups, intermittent doses of 30,000 IU twice weekly or 50,000 IU per week should be considered for a 6-8-week period only.
- Another study 2 recommends a daily dose of 2000 IU (50 µg) of vitamin D for adults in the general population, which may improve some health outcomes and is sufficient to raise and maintain serum 25(OH)D concentrations above 50 nmol/L (20 ng/mL) and above 75 nmol/L (30 ng/mL) in >99% and >90% of the general adult population, respectively. However, the study 1 provides more specific guidance for patients with increased risk of vitamin D deficiency, making it a more relevant recommendation for this population.
- It's essential to note that vitamin D is fat-soluble, and excessive intake can lead to hypercalcemia, causing symptoms like nausea, weakness, kidney problems, and in severe cases, heart rhythm abnormalities.
- Monitoring blood levels and consulting with a healthcare provider is advisable when taking vitamin D supplements, especially at doses approaching the upper limit.