From the Guidelines
Heavy THC use can potentially lower testosterone levels in men, and it is recommended to moderate cannabis consumption to minimize this effect. The relationship between THC and testosterone is complex, and research suggests that chronic cannabis consumption may disrupt the hypothalamic-pituitary-gonadal axis, which regulates testosterone production 1. This disruption can lead to decreased testosterone synthesis, reduced sperm count and quality, and in some cases, symptoms like decreased libido, fatigue, and mood changes.
Key Points to Consider
- The effect of THC on testosterone levels appears to be dose-dependent, with occasional or light users experiencing minimal or temporary effects, while heavy, long-term users may see more significant testosterone suppression 1.
- The good news is that these effects are typically reversible when cannabis use is reduced or discontinued, with hormone levels often returning to normal within weeks to months after cessation 1.
- Individual responses vary based on factors like age, overall health, and genetic predisposition.
- If you're concerned about cannabis affecting your testosterone levels, consider moderating consumption, taking breaks from use, or consulting with a healthcare provider who can monitor your hormone levels and provide personalized advice.
Clinical Guidelines and Recommendations
The American College of Physicians (ACP) guideline on testosterone treatment in adult men with age-related low testosterone does not address the specific relationship between THC and testosterone, but it does emphasize the importance of considering the potential benefits and harms of testosterone treatment in men with low testosterone levels 1. In the context of THC use, it is essential to prioritize moderation and monitor hormone levels to minimize potential adverse effects on testosterone production.
From the Research
THC and Testosterone Relationship
- The relationship between THC and testosterone is complex, with some studies suggesting a positive association and others indicating a negative correlation 2, 3.
- A study published in the Journal of Sexual Medicine found that cannabis abuse/dependence was significantly associated with erectile dysfunction (ED) and testosterone deficiency (TD) 2.
- In contrast, a study published in the World Journal of Urology found that regular THC use was associated with small increases in testosterone levels, characterized by an inverse U-shaped trend 3.
Testosterone Replacement Therapy
- Testosterone replacement therapy (TRT) has been shown to improve sexual function and hypogonadal symptoms in men with hypogonadism 4, 5.
- A study published in the Journal of Clinical Endocrinology and Metabolism found that TRT improved sexual activity, hypogonadal symptoms, and sexual desire, but not erectile function, in middle-aged and older men with hypogonadism and low libido 5.
- Another study published in Sexual Medicine Reviews found that TRT can ameliorate several aspects of sexual functioning, including libido, erectile function, and overall sexual satisfaction, but only in the presence of a hypogonadal status 6.
THC Use and Testosterone Levels
- The effect of THC on testosterone levels is not fully understood, with some studies suggesting a positive association and others indicating no significant correlation 2, 3.
- A study published in the World Journal of Urology found that regular THC use was associated with small increases in testosterone levels, but this increase declined as THC use increased 3.
- Further research is needed to fully understand the relationship between THC use and testosterone levels 2, 3.