From the FDA Drug Label
Supplement Facts Serving Size: 1 Vegetable Capsule Servings per Container: 30 Amount Per Serving % Daily Value DIM (Diindolylmethane) 150 mg * BioPerine®(black pepper fruit extract)5 mg * Broccoli 4: 1 Extract (florets)50 mg * Calcium D-Glucarate50 mg *
- Daily Value not established yet
DIM (Diindolylmethane) is a compound found in the drug label.
- The label does not specify who needs it. The FDA drug label does not answer the question.
From the Research
DIM (Diindolylmethane) is a natural compound that may benefit individuals with hormone-related conditions, particularly those with estrogen dominance symptoms, by promoting the conversion of estrogen into healthier forms. Based on the most recent and highest quality study available 1, DIM supplementation can alter the urinary estrogen profile, increasing the 2-hydroxyestrone:16-hydroxyestrone ratio, which may reduce the risk of hormone-dependent cancers and improve conditions like acne, PMS, and menopausal symptoms. The following groups may consider DIM supplementation:
- Individuals with estrogen dominance symptoms
- Women with PCOS
- Individuals with certain types of acne
- People looking to support detoxification pathways Typical supplement doses range from 100-300mg daily, though needs vary by individual. It is essential to note that while DIM is generally considered safe, some people may experience digestive upset, headaches, or darker urine when taking it. Therefore, anyone considering DIM supplements should consult with a healthcare provider first, especially those with hormone-sensitive conditions or who are pregnant, breastfeeding, or on medication. The study by 1 provides the most comprehensive evaluation to date of DIM's effect on the urinary estrogen profile, highlighting the clinical validity and utility of this approach to the evaluation of DIM supplementation. However, more research is needed to fully understand the potential clinical utility of DIM, particularly in terms of effective dosage and time frames. In contrast to earlier studies, such as 2 and 3, which suggested potential benefits and risks of DIM supplementation, the most recent study 1 provides a more comprehensive understanding of DIM's effects on estrogen metabolism. Additionally, the study by 4 found that 75mg of daily DIM supplement was ineffective in increasing the Estrogen Metabolites Urine Ratio (EMUR) in premenopausal women, but further studies are needed to evaluate the effective dosage and time frames. Overall, DIM supplementation may be a useful adjunct to traditional therapies for individuals with hormone-related conditions, but it should be used under the guidance of a healthcare provider.