From the Research
Trintellix is not the focus of the provided evidence, however, based on the available information, the question seems to be about oxandrolone, not trintellix. Given the context of the question and the provided evidence, it appears there might be a confusion in the question's subject. The evidence provided discusses oxandrolone, an anabolic steroid used for various medical conditions including severe burns, muscle wasting, and other catabolic disorders.
Oxandrolone's Use and Effects
- Oxandrolone has been shown to be effective in improving outcomes in patients with severe burns 1, 2, 3, by reducing the length of hospital stay, improving wound healing, and maintaining lean body mass.
- The medication works by promoting anabolism, which helps in recovering from catabolic states such as those induced by severe burns or other wasting conditions.
- Common side effects of oxandrolone include transient elevations in liver enzymes and changes in lipid profiles 4, 5, but it does not seem to cause the severe hepatotoxic effects associated with other anabolic steroids.
Clinical Recommendations
- For patients with severe burns, oxandrolone can be considered as part of the treatment regimen 1, 3 to improve clinical outcomes, given its benefits in reducing hospital stay and improving wound healing without significant adverse effects on liver function or mortality.
- Monitoring of liver enzymes is recommended due to potential transient elevations.
- The decision to use oxandrolone should be made on a case-by-case basis, considering the patient's overall condition, the severity of the burn, and potential interactions with other medications.
Quality of Life and Mortality
- Oxandrolone's impact on quality of life and mortality in burn patients appears to be positive 1, 3, with improvements in wound healing, reduction in hospital stay, and maintenance of lean body mass, all of which can contribute to better recovery outcomes and potentially improved quality of life.
- However, the effect on long-term mortality rates may not be significantly altered by oxandrolone treatment alone, as indicated by some studies showing no difference in mortality rates between treated and control groups 1, 3.