From the FDA Drug Label
For both treatment groups the median time to lesion healing was 9 days, the median time to cessation of pain was 5 days, and the median time to cessation of viral shedding was 3 days.
The median duration of a first presentation of HSV-2 ulcers is approximately 9 days for lesion healing, with a median of 5 days for cessation of pain and 3 days for cessation of viral shedding 1 1.
- Lesion healing: 9 days
- Cessation of pain: 5 days
- Cessation of viral shedding: 3 days
From the Research
The first presentation of HSV-2 ulcers typically lasts between 2-4 weeks if left untreated, but with proper antiviral treatment, healing may occur within 7-14 days. This initial episode is usually the most severe and prolonged compared to recurrent outbreaks. Antiviral medications can significantly reduce the duration and severity of symptoms. For a first episode, recommended treatments include acyclovir (400mg orally three times daily for 7-10 days), valacyclovir (1000mg orally twice daily for 7-10 days), or famciclovir (250mg orally three times daily for 7-10 days) 2.
Key Considerations
- The first outbreak is often accompanied by systemic symptoms like fever, body aches, and swollen lymph nodes in the groin area, which occur because the initial infection triggers a more robust immune response as the body encounters the virus for the first time.
- Pain management with over-the-counter medications and keeping the affected area clean and dry can help with comfort during healing.
- Patients should abstain from sexual activity until lesions are completely healed to prevent transmission to partners.
Treatment Options
- Acyclovir: 400mg orally three times daily for 7-10 days
- Valacyclovir: 1000mg orally twice daily for 7-10 days
- Famciclovir: 250mg orally three times daily for 7-10 days It's essential to note that while these treatments can reduce the duration and severity of symptoms, they do not cure the infection, and the virus will remain dormant in the body 3. Regular follow-up with a healthcare provider is crucial to manage the condition and prevent transmission to others.