There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for calcium d glucarate (PO) do not address this question.
From the Research
Role of Calcium D-glucarate
- Calcium D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans 1.
- It is also found in many fruits and vegetables, with the highest concentrations found in oranges, apples, grapefruit, and cruciferous vegetables 1, 2.
- Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification 1, 2, 3.
Potential Clinical Applications
- Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers 1, 2.
- Calcium D-glucarate may have potential clinical applications in the regulation of estrogen metabolism and as a lipid-lowering agent 1.
- It may also inhibit tumor development by over 70% in the 7,12-dimethylbenz[a]anthracene model of mammary tumor induction in rats 4.
- Potassium hydrogen D-glucarate has been shown to inhibit azoxymethane-induced rat colon carcinogenesis by reducing tumor incidence and multiplicity 5.
Mechanism of Action
- The mechanism of action of calcium D-glucarate involves the inhibition of beta-glucuronidase, which prevents the hydrolysis of glucuronide conjugates 2, 3.
- D-glucaro-1,4-lactone, a potent inhibitor of beta-glucuronidase, is formed from supplemented D-glucarate salt in the stomach and is absorbed from the intestinal track 2, 3.
- Calcium D-glucarate may also suppress cell proliferation and induce apoptosis, thereby exerting its anticancer action 2, 5.