From the Guidelines
Ozempic (semaglutide) may potentially contribute to sexual dysfunction in some patients, primarily through its effects on underlying conditions like diabetes, which is known to cause sexual problems via vascular and neurological mechanisms, as noted in the most recent guidelines 1. The relationship between Ozempic and sexual dysfunction is complex and not fully understood, with potential indirect effects on hormonal balance, energy levels, or psychological factors related to body changes. Key points to consider include:
- Sexual problems like decreased libido, erectile dysfunction, or changes in sexual satisfaction might occur as indirect effects of the medication.
- The connection between GLP-1 receptor agonists like Ozempic and sexual function is still being studied, and individual responses vary significantly.
- Some patients actually report improved sexual function after weight loss from Ozempic, highlighting the need for personalized assessment and management. If you experience sexual dysfunction while taking Ozempic, it is crucial not to stop the medication abruptly but to discuss your concerns with your healthcare provider, who may adjust your dose, recommend lifestyle modifications, or prescribe treatments specifically for sexual dysfunction, taking into account the latest standards of care in diabetes management 1.
From the Research
Ozempic and Sexual Dysfunction
- Ozempic, also known as semaglutide, has been associated with an increased risk of sexual dysfunction, including erectile dysfunction, in some studies 2.
- A study published in the International Journal of Impotence Research found that non-diabetic, obese men prescribed semaglutide were significantly more likely to develop erectile dysfunction and/or be prescribed phosphodiesterase type 5 inhibitors compared to a control cohort of non-diabetic men who never received a semaglutide prescription 2.
- Another study published in the Endocrine journal found that semaglutide can cause erectile dysfunction, beyond previously reported adverse reactions, in non-diabetic obese patients 3.
Mechanism and Risk Factors
- The exact mechanism of semaglutide-induced sexual dysfunction is not fully understood, but it may be related to the drug's effects on glucose and weight regulation, as well as its impact on hormone levels and blood flow 2, 3.
- Risk factors for semaglutide-induced sexual dysfunction may include dose and duration of treatment, as well as individual patient characteristics such as age, body mass index, and underlying medical conditions 2, 3.
Clinical Implications
- Healthcare providers should be aware of the potential risk of sexual dysfunction associated with semaglutide treatment and monitor patients for signs and symptoms of this condition 2, 3.
- Patients who experience sexual dysfunction while taking semaglutide should be evaluated and treated accordingly, and alternative treatments may be considered if necessary 2, 3.