From the Research
Low libido in men with hypogonadism can be effectively treated with testosterone replacement therapy (TRT), as evidenced by the most recent and highest quality study 1.
Treatment Approach
When addressing low libido, it is essential to first consult a healthcare provider to evaluate potential underlying medical causes, such as hormonal imbalances, medication side effects, or chronic conditions.
- Hormone therapy, including testosterone supplementation for men with levels below 300 ng/dL, can be an effective treatment option 1.
- Psychological approaches, such as sex therapy, cognitive behavioral therapy, or relationship counseling, are also crucial in addressing anxiety, stress, or relationship issues that may contribute to low libido.
- Lifestyle modifications, including regular exercise, stress management techniques, adequate sleep, limiting alcohol consumption, and maintaining a balanced diet, can significantly improve libido.
Testosterone Replacement Therapy
TRT has been shown to improve sexual activity, hypogonadal symptoms, and sexual desire in men with hypogonadism and low libido 1.
- The treatment should aim to achieve testosterone concentrations in the mid-normal range during treatment with any of the approved formulations, taking into consideration patient preference, pharmacokinetics, formulation-specific adverse effects, treatment burden, and cost 2.
- Clinicians should monitor men receiving TRT using a standardized plan that includes evaluating symptoms, adverse effects, and compliance, measuring serum testosterone and hematocrit concentrations, and evaluating prostate cancer risk during the first year after initiating TRT 2.
Important Considerations
- TRT is not recommended for men who are planning fertility in the near term or have certain medical conditions, such as breast or prostate cancer, palpable prostate nodule or induration, or elevated hematocrit 2.
- The use of hepatotoxic androgens should be avoided, and testosterone treatment induces reversible suppression of spermatogenesis 3.