When should the Kyleena (levonorgestrel-releasing intrauterine system) be removed?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Kyleena should be removed after 5 years of use, as this is when its contraceptive effectiveness expires. The provided evidence does not specifically mention Kyleena, but it discusses the levonorgestrel-releasing IUDs, such as Mirena and Skyla, which have approved durations of 5 years and 3 years, respectively 1. Although the exact duration of Kyleena is not mentioned, it is a levonorgestrel-releasing IUD, and its removal should be considered after 5 years of use. Some key points to consider when deciding to remove Kyleena include:

  • If you wish to continue using this method of birth control, a new Kyleena IUD can be inserted immediately after removal.
  • Kyleena should also be removed sooner if you want to become pregnant, experience severe side effects that don't improve, develop a pelvic infection that doesn't respond to antibiotics, or if the IUD becomes partially expelled or malpositioned.
  • Removal should be performed by a healthcare provider in a simple office procedure that typically takes just a few minutes, as stated in general guidelines for IUD removal 1. The timing of removal is important because Kyleena gradually releases levonorgestrel, a synthetic progestin hormone, and its ability to prevent pregnancy diminishes over time. After removal, fertility typically returns quickly, so if you don't want to become pregnant, you should start using another contraceptive method immediately, as suggested by studies on IUDs and fertility return 1.

From the Research

Removal of Kyleena

The provided studies do not specifically mention when the Kyleena should be removed. However, they do discuss the effectiveness and benefits of the levonorgestrel-releasing intrauterine system (LNG-IUS) in treating various conditions such as menorrhagia, symptomatic fibroids, endometriosis, and endometrial suppression 2, 3, 4, 5, 6.

General Information on LNG-IUS

  • The LNG-IUS is an effective and safe form of long-term yet reversible birth control 2.
  • It offers potential therapeutic benefits in other clinical contexts, including menorrhagia, symptomatic fibroids, endometriosis, and endometrial suppression 2.
  • The LNG-IUS consistently reduces menstrual blood loss in women with heavy menstrual bleeding, including those with underlying uterine pathology or bleeding disorders 3, 4.
  • It improves health-related quality of life significantly at relatively low cost and is comparable to surgical interventions such as hysterectomy 3, 4.

Removal Considerations

Although the studies do not provide specific guidance on when to remove the Kyleena, they do mention that the LNG-IUS can be removed at any time, and fertility typically returns quickly after removal 2. However, the decision to remove the device should be based on individual patient needs and circumstances, which are not discussed in the provided studies.

References

Related Questions

What is the most effective form of contraception for a woman with Down syndrome to achieve amenorrhea (absence of menstruation)?
What is the most effective contraceptive for managing menorrhagia (heavy menstrual bleeding)?
What is the mechanism of action, effect, and dosage of the Levonorgestrel (LNG)-releasing Intrauterine Device (IUD)?
Is it appropriate to switch a 19-year-old female from Larin 1/20 (ethinyl estradiol and norethindrone) to a levonorgestrel intrauterine device (LNG-IUD) for long-acting reversible contraception and continued menstrual control, given her history of anxiety and recent improvement in menstrual symptoms?
What is the best approach to manage heavy menstrual bleeding in a 14-year-old girl with cerebral palsy (CP), spasticity, and a history of preterm birth at 25 weeks gestation, who experiences monthly bleeding lasting 8 days with clot passage and requires frequent pad changes?
Is a streptococcal (strep) culture helpful after initiating Augmentin (amoxicillin-clavulanate) therapy?
What type of electroencephalogram (EEG) is indicated for a possible seizure?
What is the diagnosis of fibromyalgia (Fibromyalgia Syndrome)?
What is the diagnosis for a 13-week pregnant patient (Gravida 3, Para 2, Abortions 0, Living children 2) with a history of anxiety, currently experiencing mild lumbopelvic pain, headache, and nausea, while being treated with Broxatan (Bromazepam) and Gamalate B6 (Pyridoxine), presenting with a fetal cardiac frequency of 134 beats per minute and mild infraumbilical tenderness?
What is the step-by-step operative procedure for open reduction and internal fixation (ORIF) of a right-sided iliac fracture with sacroiliac (SI) joint fracture using plating?
Are there concerns with pancreatic cysts and liver adenoma when initiating Glucagon-like peptide-1 (GLP-1) receptor agonists?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.