From the Research
It is strongly recommended to avoid alcohol while taking Augmentin (amoxicillin/clavulanic acid) to minimize the risk of liver-related side effects and ensure the effectiveness of the antibiotic treatment. While there is no direct dangerous interaction between Augmentin and alcohol, combining them can worsen side effects like nausea, dizziness, and stomach upset. Both substances can independently cause gastrointestinal distress, and alcohol may reduce your body's ability to fight infection effectively, potentially interfering with the antibiotic's purpose. Additionally, alcohol can stress your liver, which is also responsible for metabolizing Augmentin, potentially increasing the risk of liver-related side effects, as seen in a case report of a 22-year-old female who developed drug-induced liver injury after taking amoxicillin-clavulanate 1.
Some key points to consider when taking Augmentin include:
- Completing the entire prescribed course of Augmentin (typically 7-10 days) to ensure effective treatment of the infection
- Taking the medication with food to minimize stomach upset
- Staying well-hydrated to help your body absorb the antibiotic
- Being aware of potentially intensified side effects if you do consume alcohol while on this medication
- Following your healthcare provider's specific instructions regarding your treatment, as they can provide personalized guidance based on your individual needs and medical history.
It's also important to note that the risk of liver-related side effects may be higher in certain individuals, such as those with underlying liver disease or the elderly, as suggested by a study on the determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity 2. However, the most recent and highest quality study on the treatment of alcohol use disorder in patients with alcohol-associated liver disease found that AUD treatment improves abstinence and liver-related outcomes, both outside and within liver transplantation settings 3.