There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the Research
Treatment of Toxic Shock Syndrome
- Toxic Shock Syndrome (TSS) is a severe, toxin-mediated illness that requires prompt recognition and treatment 1
- Treatment involves intravenous fluids, source control, and antibiotics 1, 2, 3
- Antibiotics should include a penicillinase-resistant penicillin, cephalosporin, or vancomycin (in methicillin-resistant S. aureus prevalent areas) along with either clindamycin or linezolid 1
- Patients with TSS usually have a focus of staphylococcal infection that should be adequately drained and treated with antimicrobial therapy 4, 2
Outpatient Treatment
- There is no evidence to suggest that TSS can be treated on an outpatient basis, as it is a potentially deadly disease that requires prompt recognition and treatment in a hospital setting 4, 1, 2, 3, 5
- Patients with TSS often require large volumes of fluid and close monitoring, which is typically not feasible in an outpatient setting 2
- Hospitalization is usually necessary to manage the disease and prevent complications, such as multiple organ failure 4, 1, 2, 3, 5