What could be causing intermenstrual bleeding in a woman with a regular 28-day menstrual cycle?

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Differential Diagnosis for Heavy Bleeding

The following is a list of potential causes for heavy bleeding outside of the regular menstrual cycle:

  • Single most likely diagnosis
    • Breakthrough bleeding due to hormonal contraception: This is a common cause of irregular bleeding, especially in women who have recently started or changed their hormonal contraceptive method.
  • Other Likely diagnoses
    • Ovulatory dysfunction: Irregular ovulation can lead to changes in menstrual bleeding patterns, including heavy bleeding at unexpected times.
    • Uterine fibroids: These non-cancerous growths in the uterus can cause heavy or irregular bleeding.
    • Endometrial polyps: Growths on the lining of the uterus can lead to abnormal bleeding.
    • Infection or inflammation: Pelvic inflammatory disease (PID) or other infections can cause irregular bleeding.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Ectopic pregnancy: Although unlikely if the patient is using hormonal contraception, an ectopic pregnancy can cause irregular bleeding and is a life-threatening condition if not promptly diagnosed.
    • Malignancy: Uterine or cervical cancer can cause abnormal bleeding, and early detection is crucial for effective treatment.
    • Bleeding disorders: Conditions like von Willebrand disease or other coagulopathies can increase the risk of heavy bleeding.
  • Rare diagnoses
    • Thyroid disorders: Both hyperthyroidism and hypothyroidism can affect menstrual bleeding patterns.
    • Pituitary tumors: Rare tumors in the pituitary gland can disrupt hormonal balance, leading to irregular bleeding.
    • Adenomyosis: A condition where tissue similar to the lining of the uterus grows into the uterine walls, causing heavy or irregular bleeding.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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