From the Guidelines
Nasal steroid sprays can be used safely by individuals with Mast Cell Activation Syndrome (MCAS) who are taking quercetin, as there is high-quality evidence supporting their safety and efficacy in treating chronic rhinosinusitis 1. For most patients, medications like fluticasone (Flonase), mometasone (Nasonex), or budesonide (Rhinocort) can be used as directed on the packaging, typically 1-2 sprays per nostril once or twice daily. However, some MCAS patients may be sensitive to preservatives or propellants in certain nasal spray formulations. If you're concerned about potential reactions, start with a single spray in one nostril as a test dose and monitor for any adverse reactions before continuing regular use. Quercetin, as a mast cell stabilizer, may actually complement the anti-inflammatory effects of nasal steroids by reducing histamine release through different mechanisms. The steroids work primarily by reducing inflammatory pathways, while quercetin helps stabilize mast cells directly. Key benefits of nasal steroid sprays include:
- Improvement in nasal symptoms
- Enhancement of quality of life
- Effective long-term treatment for chronic rhinosinusitis, as supported by the European position paper on rhinosinusitis and nasal polyps 2020 1. If you experience worsening symptoms after using nasal steroids, discontinue use and consult your healthcare provider who specializes in MCAS, as they may recommend a preservative-free formulation or alternative treatment approach.
From the Research
Nasal Steroid Sprays and MCAS
- There is no direct evidence in the provided studies regarding the safety of nasal steroid sprays for individuals with Mast Cell Activation Syndrome (MCAS) taking Quercetin.
- However, it is known that patients with MCAS may experience symptoms of mast cell activation, which can be managed by various treatments, including blockade of mediator receptors and inhibition of mediator synthesis 2.
- Quercetin is often used as a natural antihistamine and anti-inflammatory agent, and some patients with MCAS may use it to help manage their symptoms.
- The use of nasal steroid sprays in patients with MCAS is not explicitly mentioned in the provided studies, but corticosteroids are sometimes used to address prolonged episodes of mast cell activation 2.
- It is essential to note that MCAS is a complex condition, and treatment approaches may vary depending on the individual patient's needs and symptoms 3, 4, 5, 6.
Considerations for Treatment
- Patients with MCAS often require a personalized treatment plan, and healthcare providers should be aware of the potential interactions between different medications and supplements 6.
- The diagnosis and management of MCAS can be challenging, and healthcare providers should be prepared to work with patients to develop effective symptom-management strategies 3, 4, 5, 2, 6.
- Further research is needed to fully understand the mechanisms and pathways involved in MCAS and to develop more effective treatment approaches 5.