From the Guidelines
DMT, or N,N-Dimethyltryptamine, is a powerful psychedelic compound that alters perception and consciousness by binding to serotonin receptors in the brain, particularly the 5-HT2A receptor, resulting in intense, short-lasting hallucinogenic experiences. When considering the morbidity, mortality, and quality of life outcomes associated with DMT use, it is essential to acknowledge the potential risks and benefits. According to a systematic review of research on low-dose psychedelics, including DMT, increased intensity, somaesthesia, and reduced volition have been reported following microdoses 1. Some key points to consider about DMT include:
- Its ability to produce visual and auditory hallucinations, altered perception of time, and profound mystical or spiritual experiences that users often describe as life-changing
- The effects of DMT when smoked usually last 5-20 minutes but can feel much longer to the user
- Its classification as a Schedule I controlled substance in the United States, making it illegal to possess or distribute
- Ongoing research into its potential therapeutic applications for conditions like depression and anxiety, though this research is still preliminary 1. The neurobiological and physiological effects of DMT have been studied using various measures, including the 5D-ASC, which provides a comprehensive assessment of alterations in consciousness 1. Overall, the use of DMT should be approached with caution, considering both the potential benefits and risks to morbidity, mortality, and quality of life.
From the Research
Definition and Composition of DMT
- DMT stands for Dimethyltryptamine, a potent, rapid-onset, and short-acting psychedelic drug 2
- It is an indole alkaloid produced by a number of plants and animals, including humans 3
Therapeutic Potential of DMT
- DMT has been investigated for its potential therapeutic effects in treating depression, anxiety, and substance dependence 2, 4, 3
- Studies have shown that DMT may have rapid antidepressant effects in patients with treatment-resistant major depressive disorder 2
- Ayahuasca, a plant-based psychedelic that contains DMT, has promising results in anxiety, depression, and substance dependence 3
Psychological and Physiological Effects of DMT
- DMT induces a rapid and transient altered state of consciousness when inhaled or injected via bolus administration 5
- It can increase blood pressure, heart rate, anxiety, psychedelic effects, and psychotomimetic effects, which resolve within 20-30 minutes of injection 2
- Extended administration of DMT has been shown to be safe and effective, with subjective effects maintained over the period of active infusion and low anxiety ratings 5