What is the diagnosis for a patient with leukocytosis and neutrophilia?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 17, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis

The patient's laboratory results show an elevated white blood cell (WBC) count with a predominance of neutrophils. The following differential diagnoses are considered:

  • Single Most Likely Diagnosis
    • Bacterial Infection: The elevated neutrophil count suggests a bacterial infection, which is a common cause of neutrophilia. The patient's clinical presentation and other laboratory results would help confirm this diagnosis.
  • Other Likely Diagnoses
    • Viral Infection: Some viral infections, such as influenza or respiratory syncytial virus, can cause a mild increase in WBC count with neutrophilia.
    • Inflammatory Condition: Conditions like rheumatoid arthritis, gout, or other inflammatory diseases can cause an increase in WBC count with neutrophilia.
    • Stress or Trauma: Physical stress or trauma can cause an increase in WBC count with neutrophilia due to the release of stress hormones like cortisol and adrenaline.
  • Do Not Miss (Deadly if Missed)
    • Sepsis: Although the patient's WBC count is not extremely high, sepsis is a life-threatening condition that requires prompt diagnosis and treatment. A high index of suspicion is necessary, especially if the patient has a fever, hypotension, or other signs of organ dysfunction.
    • Leukemia: Although less likely, leukemia can cause an elevated WBC count with neutrophilia. A bone marrow biopsy or further laboratory tests would be necessary to confirm this diagnosis.
  • Rare Diagnoses
    • Myeloproliferative Neoplasm: Conditions like polycythemia vera or essential thrombocythemia can cause an increase in WBC count with neutrophilia.
    • Chronic Granulomatous Disease: A rare genetic disorder that affects the immune system and can cause recurrent infections and an increase in WBC count with neutrophilia.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.