What supplements, in addition to vitamin D and calcium, can decrease the risk of preeclampsia in a pregnant woman with an allergy to aspirin (acetylsalicylic acid)?

From the Research

For pregnant women at risk of preeclampsia who are allergic to aspirin, the recommended supplementation regimen is:

1. Vitamin D: 1000-2000 IU daily
2. Calcium: 1000-1500 mg daily (divided into 2-3 doses)
3. Low-dose magnesium: 200-400 mg daily Start these supplements early in pregnancy and continue throughout. Take calcium separately from iron supplements or prenatal vitamins containing iron, as they can interfere with absorption. Vitamin D helps regulate blood pressure and supports immune function. Calcium is crucial for blood pressure regulation and may reduce the risk of hypertensive disorders in pregnancy. Magnesium supports blood pressure control and can help prevent muscle cramps. While not as effective as aspirin, this combination may help reduce preeclampsia risk. Maintain a healthy diet, regular prenatal check-ups, and monitor blood pressure closely. Consult your healthcare provider about other potential interventions suitable for your specific situation.

The evidence from the study by 1 suggests that calcium and vitamin D supplementation can lower the risk of preeclampsia, with a pooled risk ratio of 0.54 for calcium and 0.47 for vitamin D. Although the studies 2, 3, and 4 discuss the effectiveness of aspirin in preventing preeclampsia, they are not directly relevant to the question of alternative supplements for women allergic to aspirin. The study by 5 also discusses the use of aspirin and screening for preeclampsia, but does not provide information on alternative supplements. Therefore, the recommended supplementation regimen is based on the available evidence from 1.

Some key points to consider:

• The American College of Obstetricians and Gynecologists (ACOG) recommends calcium supplementation for pregnant women at high risk of preeclampsia, but does not specify a particular dose.
• The evidence for magnesium supplementation is limited, but it may help reduce blood pressure and prevent muscle cramps.
• It is essential to consult with a healthcare provider before starting any supplements, especially for women with a history of allergies or medical conditions.
• Regular prenatal check-ups and monitoring of blood pressure are crucial for early detection and management of preeclampsia.