Does 6000 units of nattokinase (NK) have an anticoagulant effect?

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Last updated: May 21, 2025View editorial policy

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From the Research

Yes, 6000 units of nattokinase does have blood thinning effects, as evidenced by its fibrinolytic properties, which can help break down blood clots and reduce blood viscosity, as shown in a study published in 2022 1. Nattokinase is an enzyme derived from natto (fermented soybeans) that has been found to have antiatherosclerotic and lipid-lowering effects, in addition to its blood thinning properties.

  • At a dose of 6000 units, which is considered a relatively high dose, the blood thinning effect is significant, and may interact with prescription blood thinners like warfarin, aspirin, or other anticoagulant/antiplatelet medications, potentially increasing bleeding risk, as noted in a study from 2021 2.
  • This enzyme works by degrading fibrin, a protein involved in blood clotting, and may also inhibit the activity of plasminogen activator inhibitor type 1 (PAI-1), which normally prevents the breakdown of blood clots.
  • If you're considering taking nattokinase at this dosage, it's essential to be aware of the potential risks and benefits, and to consult with a healthcare provider before starting, especially at higher doses like 6000 units, as recommended by a review published in 2018 3. Some key points to consider when taking nattokinase include:
  • Discontinuing nattokinase at least two weeks before any surgical procedure to reduce bleeding complications.
  • Avoiding nattokinase if you have bleeding disorders, uncontrolled high blood pressure, or are pregnant or breastfeeding.
  • Monitoring your condition closely while taking nattokinase, especially if you're also taking other medications that may interact with it, as shown in a study from 2021 4. It's also important to note that while nattokinase may have benefits for cardiovascular health, it should not be used as a replacement for established medical treatments, but rather as a complementary therapy under the guidance of a healthcare provider, as suggested by a study published in 2017 5 is not directly relevant to the question of nattokinase's blood thinning effects.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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