From the Guidelines
Iron is crucial for the human body as it plays a central role in oxygen transport, energy production, and various biological processes, with approximately two-thirds of the body's iron being localized in the erythropoietic system and red blood cells. The importance of iron is highlighted in a 2021 study published in Blood Reviews, which notes that iron is indispensable for the normal development and function of all tissues in the human body 1. This study emphasizes the critical roles of iron in many biological processes, including oxygen transport via the iron-containing heme component of hemoglobin (Hb).
Some key points about iron's importance in the body include:
- Iron is essential for the production of healthy red blood cells, with iron deficiency leading to iron deficiency anemia characterized by fatigue, weakness, and decreased immune function 1
- Iron supports proper brain development and cognitive function, particularly in children 1
- Iron is necessary for various enzyme reactions involved in metabolism and DNA synthesis, with approximately 400 genes encoding iron-proteins 1
- Iron-containing proteins play important roles in cellular respiration, biosynthesis of Fe/S cluster containing proteins, and regulation of gene expression 1
In terms of dietary recommendations, most adults need about 8-18 mg of iron daily, with women of childbearing age requiring higher amounts due to menstrual blood loss. Good dietary sources of iron include:
- Red meat
- Poultry
- Fish
- Beans
- Lentils
- Spinach
- Iron-fortified cereals
For individuals with diagnosed iron deficiency, supplements like ferrous sulfate may be recommended, although these should be taken on an empty stomach with vitamin C to enhance absorption 1. However, it is essential to note that both iron deficiency and iron overload can have potentially adverse clinical effects, and a highly sophisticated regulation of iron homeostasis is necessary to maintain optimal iron levels in the body 1.
From the FDA Drug Label
Each tablet contains 324mg of ferrous sulfate, equivalent to 65mg of elemental iron, providing 362% of the U.S. recommended daily intake (RDI) of iron for adults and children 4 and older. Each tablet contains 324 mg of ferrous sulfate, equivalent to 65 mg of elemental iron, providing 362% of the U.S. recommended daily intake (RDI) of iron for adults and children 4 and older.
The importance of iron for the body is not directly stated in the provided drug labels. However, the fact that the labels mention the U.S. recommended daily intake (RDI) of iron suggests that iron is a necessary nutrient.
- The labels imply that iron is essential by providing a high percentage of the daily recommended intake, but they do not explicitly state why iron is important for the body 2 2.
From the Research
Importance of Iron for the Body
- Iron is essential for various bodily functions, including oxygen transport, short-term oxygen storage, and energy generation 3
- It plays a crucial role in the production of hemoglobin, myoglobin, and cytochromes, which are vital for maintaining homeostasis and health 3
- Iron deficiency can have severe consequences, including anemia, behavioral and learning disorders in children, and other adverse effects on the body 3
Role of Iron in Human Health
- Iron is necessary for the proper functioning of various nonheme-containing enzymes, which are involved in different biological processes 3
- The body's iron balance is controlled by the rate of iron absorption, and there are no physiologic mechanisms to excrete excess iron 3
- Maintaining proper iron balance is essential for preventing iron deficiency and iron excess, both of which can be toxic to the body 3
Treatment of Iron Deficiency
- Intravenous iron therapy is an effective treatment for iron deficiency anemia, particularly in patients who are intolerant or unresponsive to oral iron 4, 5, 6, 7
- High-dose intravenous iron can be used as a first-choice therapy in outpatients with severe iron deficiency anemia, with a significant increase in hemoglobin levels and minimal side effects 7
- The choice of iron therapy depends on various factors, including the presence of inflammation, the time available for iron replenishment, and the anticipated risk of side-effects or intolerance 5