From the Research
The maximum recommended dose of bleomycin for wart treatment is up to 3 mL per session, with a concentration of 1.5 U/mL, as supported by the study published in 2006 1. This dose can be administered in multiple injections, with the total dose depending on the size of the lesion.
- The dose ranged from 0.25 to 1.0 mL per injection per lesion in the study 1.
- Treatment sessions should be spaced according to the clinical response, with most patients requiring one or two injections for complete resolution, as shown in the study 1.
- Bleomycin should be injected directly into the wart using a suitable needle until blanching occurs.
- This treatment is typically reserved for recalcitrant warts that have failed other therapies.
- Bleomycin works by causing DNA damage and inducing apoptosis in infected cells, effectively destroying the wart tissue.
- Side effects include pain during injection, local necrosis, and potential nail changes when used for periungual warts.
- A more recent study published in 2021 2 used a concentration of 1 mg/ml, but the study from 2006 1 provides a clearer guideline for the maximum dose.
- Other studies, such as those published in 1986 3, 1980 4, and 2014 5, provide additional information on the treatment of warts, but the study from 2006 1 is the most relevant to the question of maximum dose.