From the Guidelines
CBD gummies and oil should be used with caution, starting with a low dose of 5-10mg, due to potential risks of hepatotoxicity and interactions with other medications, as highlighted in the 2024 ASCO guideline 1. When considering CBD products, it's essential to prioritize morbidity, mortality, and quality of life. The current evidence suggests that CBD may help with anxiety, pain, and sleep issues, but its effects vary between individuals.
- Key considerations for using CBD gummies and oil include:
- Starting with a low dose and gradually increasing as needed
- Being aware of potential side effects, such as drowsiness, dry mouth, and hepatotoxicity
- Looking for products with third-party testing to verify CBD content and confirm they contain less than 0.3% THC
- Consulting a healthcare provider before starting CBD, especially if taking other medications or having underlying health conditions The 2024 ASCO guideline 1 emphasizes the importance of minimizing adverse effects, particularly in older adults and those naive to cannabis and/or cannabinoids.
- To minimize risks, it's crucial to:
- Start with a low dose and slowly increase until the desired effect is achieved
- Be aware of the potential for cannabis and/or cannabinoid overdoses, which can be distressing and increase the risk of falls and healthcare utilization
- Monitor for signs of hepatotoxicity, as CBD presents risks for liver damage, as noted in the meta-analysis 1. Overall, while CBD gummies and oil may offer potential benefits, it's essential to approach their use with caution and prioritize individual health and safety, as supported by the highest quality and most recent evidence 1.
From the Research
CBD Gummies and Oil Overview
- CBD gummies and oil are products derived from Cannabis sativa, with CBD being a non-psychoactive component [(2,3)].
- These products are widely available and marketed as potential treatments for various health conditions, including anxiety, pain, and sleep disorders [(4,5)].
Therapeutic Efficacy and Safety
- There is clear evidence supporting the utility of CBD to treat epilepsy 3.
- For other health conditions, evidence is often mixed, and rigorous, controlled studies are lacking 3.
- Possible concerns with CBD use include adverse effects, drug-drug interactions, and lack of regulatory oversight [(3,6)].
Product Labeling and Regulation
- Accurate and informative labeling of CBD products is crucial for protecting consumers and enabling informed decision-making 2.
- Untruthful or unsubstantiated health-related claims and unallowed drug claims on labels may create harm 2.
- Manufacturers should understand and adhere to FDA regulations for labeling and marketing of food, dietary supplements, and drugs 2.
User Knowledge and Attitudes
- Many users are not knowledgeable about legal and regulatory issues surrounding CBD products 5.
- Users often report using guesswork to determine dosage, and some experience unanticipated side effects 5.
- Public health professionals should address alternative stress and anxiety treatment methods due to the lack of comprehensive regulation and research on CBD use 5.