How long is hand, foot, and mouth disease (HFMD) contagious after the rash appears?

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Last updated: May 27, 2025View editorial policy

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From the Guidelines

Hand, foot, and mouth disease typically remains contagious for about 7-10 days after the rash appears, but the provided evidence does not directly address this question, so this answer is based on general medical knowledge. However, people are most contagious during the first week of illness, particularly during the fever stage before the rash develops. The virus can be present in stool for several weeks after symptoms resolve, so proper hand hygiene remains important even after visible symptoms disappear.

Key Points to Consider

  • The disease spreads through contact with an infected person's saliva, respiratory secretions, fluid from blisters, and feces.
  • Children should stay home from school or daycare until fever is gone and mouth sores have healed enough that they're not drooling excessively.
  • This recommendation helps prevent transmission since the virus primarily spreads when people are symptomatic.
  • The causative agents are enteroviruses (most commonly Coxsackievirus A16 and Enterovirus 71) which can survive on surfaces, so regular cleaning of potentially contaminated items and surfaces is also important for preventing spread.

Relevant Information from Studies

The provided studies do not directly address the contagious period of hand, foot, and mouth disease, but they discuss the contagiousness of other diseases, such as varicella 1 and influenza 1.

Decision Making

Based on general medical knowledge, it is recommended that children with hand, foot, and mouth disease should stay home from school or daycare until they are no longer contagious, which is typically around 7-10 days after the rash appears. Proper hand hygiene and regular cleaning of potentially contaminated items and surfaces are also crucial in preventing the spread of the disease.

From the Research

Contagious Period of Hand Foot Mouth Disease

  • The contagious period of hand foot mouth disease is not explicitly stated in the provided studies as being directly related to the appearance of the rash.
  • However, according to 2, lesions usually resolve in seven to 10 days, and the disease is transmitted by fecal-oral, oral-oral, and respiratory droplet contact.
  • It can be inferred that the contagious period may last as long as the disease is active, which is typically around 7-10 days 2, 3, 4.
  • The best methods to prevent the spread of hand-foot-and-mouth disease are handwashing and disinfecting potentially contaminated surfaces and fomites 2.
  • Vaccination of susceptible individuals in high-risk areas and good personal hygiene are also important preventative measures to combat the disease 3, 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Hand-Foot-and-Mouth Disease: Rapid Evidence Review.

American family physician, 2019

Research

Hand, Foot, and Mouth Disease: A Narrative Review.

Recent advances in inflammation & allergy drug discovery, 2022

Research

Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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