From the Research
Aripiprazole is the recommended antipsychotic medication for treating delusional disorder due to its effectiveness and good tolerability, as evidenced by a systematic review published in 2020 1. The treatment of delusional disorder typically involves the use of antipsychotic medications, and the choice of medication should be based on the patient's specific symptoms, medical history, and potential side effects.
- The average dose of aripiprazole used in the treatment of delusional disorder is 11.1 mg/day, with an average time to achieve a clinical response of 5.7 weeks 1.
- Few adverse effects have been reported with the use of aripiprazole, including asthenia, extrapyramidal symptoms, hyperprolactinemia, and insomnia 1.
- While other antipsychotic medications, such as risperidone, olanzapine, and quetiapine, may also be effective in treating delusional disorder, the evidence for aripiprazole is more recent and of higher quality 1.
- Psychotherapy, particularly cognitive behavioral therapy, is an important adjunct to medication in the comprehensive treatment of delusional disorder, although the evidence for its effectiveness is limited 2.
- Regular monitoring for metabolic effects, movement disorders, and other adverse reactions is essential when using antipsychotic medications to treat delusional disorder.
- The medication regimen should continue for at least 6-12 months after symptom resolution, with some patients requiring longer-term maintenance therapy.
- Clinicians should consider the patient's specific symptoms, medical history, potential drug interactions, and side effect profile when selecting a medication for the treatment of delusional disorder.