What laboratory tests are affected by prolonged exposure to Red Blood Cells (RBCs)?

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From the Guidelines

Prolonged exposure to red blood cells (RBCs) can significantly affect laboratory tests, particularly those measuring folate status, as RBC folate levels reflect long-term folate status and can be altered by prolonged exposure to RBCs. When considering the impact of prolonged exposure to RBCs on laboratory tests, it is essential to recognize that this can lead to changes in various parameters due to the continued metabolism and leakage of intracellular contents from RBCs. The key laboratory tests affected by prolonged exposure to RBCs include:

  • Folate status, as measured by RBC folate levels, which can be altered due to the prolonged exposure, potentially leading to inaccurate assessments of long-term folate status 1.
  • Other tests may also be indirectly affected, such as plasma homocysteine concentrations, which are used as a functional marker of folate status but can also be influenced by the status of vitamins B2, B6, and B12, as well as renal impairment 1. It is crucial to process blood samples promptly, ideally within a short timeframe of collection, and store them appropriately if processing is delayed to minimize the effects of prolonged RBC exposure on laboratory results. Understanding these effects is vital for the accurate interpretation of laboratory results, especially when sample processing is delayed, to ensure that any abnormalities detected are genuinely reflective of the patient's condition rather than artifacts of prolonged RBC exposure. In the context of folate status assessment, using the gold standard technique of microbiological assay (MBA) with Lactobacillus rhamnosus, and taking pre-analytical precautions to protect folate from degradation, can help ensure reliable results 1.

From the Research

Laboratory Tests Affected by Prolonged Exposure to RBCs

Prolonged exposure to red blood cells (RBCs) can lead to abnormal laboratory test results due to hemolysis, the breakdown of RBCs. The following laboratory tests can be affected:

  • Complete Blood Count (CBC) with differential 2, 3, 4
  • Reticulocyte count 2, 5
  • Lactate dehydrogenase (LDH) levels 5
  • Unconjugated bilirubin levels 5
  • Haptoglobin levels 5
  • Direct antiglobulin test 5
  • Peripheral blood smear 5
  • Red blood cell indices, including mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration, and red cell distribution width 2, 4
  • Hemoglobin and hematocrit levels 2, 4
  • White blood cell count and differential 2, 4
  • Platelet count 2

Mechanisms of Hemolysis

Hemolysis can occur through various mechanisms, including:

  • Poor deformability leading to trapping and phagocytosis 5
  • Antibody-mediated destruction through phagocytosis or direct complement activation 5
  • Fragmentation due to microthrombi or direct mechanical trauma 5
  • Oxidation 5
  • Direct cellular destruction 5

Clinical Interpretation of Laboratory Results

The interpretation of laboratory results requires a comprehensive understanding of the strengths, limitations, and clinical implications of each test 6, 3. A structured approach to evaluating abnormal laboratory results can help clinicians recognize when a subspecialty consultation is necessary and when it may be circumvented 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The complete blood count: physiologic basis and clinical usage.

The Journal of perinatal & neonatal nursing, 1997

Research

Understanding the complete blood count with differential.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2003

Research

Hemolytic Anemia: Evaluation and Differential Diagnosis.

American family physician, 2018

Research

The chemical and laboratory investigation of hemolysis.

Advances in clinical chemistry, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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