What is the dosage of fluticasone (Flonase) for nasal spray?

From the Guidelines

The recommended dosage for fluticasone nasal spray is 50 µg per spray, with a dosing regimen of 1 spray per nostril every day for ages 4 years to adult, and 2 sprays per nostril every day for adults. This is based on the most recent and highest quality study available, which is the clinical practice guideline for allergic rhinitis published in 2015 1. The study provides a comprehensive overview of intranasal steroids, including fluticasone propionate, and recommends a dosage of 50 µg per spray for the treatment of allergic rhinitis.

Some key points to consider when using fluticasone nasal spray include:

• Starting with the lowest effective dose and adjusting as needed for symptom control
• Shaking the bottle gently before each use and priming the pump before first use
• Potential side effects, such as nasal irritation, headache, or nosebleeds
• Consulting a healthcare provider if symptoms persist beyond 7 days of regular use

It's worth noting that fluticasone works by reducing inflammation in the nasal passages, which helps relieve symptoms of allergic rhinitis such as sneezing, itching, and runny nose. The dosing regimen may vary depending on the specific prescription strength and the patient's age, but the recommended dosage of 50 µg per spray is a general guideline for most patients 1.

From the FDA Drug Label

DOSAGE AND ADMINISTRATION Patients should use Fluticasone Propionate Nasal Spray, USP, at regular intervals for optimal effect. Adults The recommended starting dosage in is 2 sprays (50 mcg of fluticasone propionate each) in each nostril once daily (total daily dose, 200 mcg). The maximum total daily dosage should not exceed 2 sprays in each nostril (200 mcg/day).

The recommended dosage of fluticasone propionate nasal spray is 200 mcg per day, with a maximum of 200 mcg per day. Since each spray contains 50 mcg of fluticasone propionate, this corresponds to 4 mg of fluticasone propionate per day (200 mcg = 0.2 mg, and 0.2 mg x 10 = 2 mg for 2 sprays in each nostril, but the question is about fluticason, not fluticasone propionate) 2.

However, the question asks about fluticason, not fluticasone propionate. Since the active ingredient in the nasal spray is fluticasone propionate, not fluticason, and assuming fluticason is a typo and the question meant fluticasone, the answer would be that each spray contains 50 mcg of fluticasone propionate.

• The daily dose is 200 mcg.
• Each spray is 50 mcg.
• The question is about mg, so 200 mcg is 0.2 mg or 200 micrograms. Since the question is about fluticason, and there is no information about fluticason in the label, the correct answer should be based on the information available for fluticasone propionate.

The FDA drug label does not answer the question.

From the Research

Dosage of Fluticasone for Nasal Spray

• The dosage of fluticasone for nasal spray is not explicitly stated in milligrams (mg) in the provided studies, but it is mentioned in micrograms (μg) per spray.
• In the study 3, fluticasone furoate (FF) was administered at a dose of 27.5 μg/spray, twice daily.
• It is essential to note that the dosage may vary depending on the specific formulation and brand of the nasal spray, as well as the individual patient's needs and medical history.
• There is no direct information available in the provided studies to convert the dosage from micrograms to milligrams, but it can be calculated by dividing the microgram dose by 1000 (since 1 mg = 1000 μg).
• For example, the dose of 27.5 μg/spray can be converted to milligrams by dividing by 1000, resulting in 0.0275 mg/spray.
• However, it is crucial to consult the specific product labeling or a healthcare professional for accurate dosage information and guidance on using fluticasone nasal spray.

Key Findings

• The studies 3, 4, 5, 6, 7 discuss the efficacy and safety of fluticasone and azelastine nasal sprays in treating allergic rhinitis, but do not provide a direct answer to the question of the dosage in milligrams.
• The studies suggest that fluticasone and azelastine nasal sprays are effective in reducing symptoms of allergic rhinitis, and combination therapy may be more effective than monotherapy in some cases 4, 7.