From the Guidelines
Ryaltris nasal spray should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ryaltris contains two active ingredients: olopatadine (an antihistamine) and mometasone furoate (a corticosteroid). While there is limited human pregnancy data specifically for Ryaltris, mometasone has been used in pregnancy with no clear evidence of harm, though some animal studies have shown adverse effects at high doses 1. Olopatadine has less pregnancy safety data available.
Key Considerations
- The safety of intranasal corticosteroids, such as mometasone, during pregnancy is supported by studies showing no increased risk of major malformations, preterm delivery, low birth weight, and pregnancy-induced hypertension 1.
- First-generation antihistamines should be avoided due to their sedative and anticholinergic properties, but there is less guidance on the use of second-generation antihistamines like olopatadine during pregnancy 1.
- If allergic rhinitis symptoms are severe enough to impact maternal health and quality of life, healthcare providers may consider Ryaltris after discussing the risks and benefits.
Alternative Treatments
- Alternative treatments with more established safety profiles in pregnancy, such as certain oral antihistamines (like cetirizine or loratadine) or single-ingredient intranasal corticosteroids with more pregnancy data, might be preferable first-line options.
- Always consult with your healthcare provider before using any medication during pregnancy to make an individualized decision based on your specific situation and symptom severity.
Decision Making
- The decision to use Ryaltris during pregnancy should be made after careful consideration of the potential benefits and risks, and in consultation with a healthcare provider.
- It is essential to weigh the potential benefits of symptom relief against the potential risks to the fetus, and to consider alternative treatments with more established safety profiles.
From the Research
Safety of Ryaltris Nasal Spray in Pregnancy
- There are no research papers provided that directly address the safety of Ryaltris nasal spray in pregnancy.
- The studies provided focus on the efficacy and safety of azelastine hydrochloride and fluticasone propionate in treating allergic rhinitis in various populations, including children and adults 2, 3, 4, 5, 6.
- None of the studies mention pregnancy or the safety of Ryaltris nasal spray in pregnant women.
- Therefore, there is no available evidence to assist in answering this question.