What are the causes, prevention, and treatment of Clostridium perfringens food poisoning?

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Last updated: May 31, 2025View editorial policy

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From the Guidelines

Clostridium perfringens food poisoning is typically caused by consuming contaminated meat and poultry dishes that have been improperly cooled or held at inadequate temperatures after cooking. The most common sources of C. perfringens food poisoning include:

  • Meat and poultry dishes, such as roasted meats, stews, and soups
  • Gravy and sauces made from contaminated meat
  • Other foods that have come into contact with contaminated meat or poultry

Prevention involves proper food handling practices, including:

  • Cooking foods thoroughly to at least 165°F 1
  • Cooling cooked foods rapidly from 140°F to 70°F within 2 hours and to 41°F within 4 hours 1
  • Reheating leftovers to at least 165°F
  • Maintaining hot foods above 140°F and cold foods below 41°F

Treatment is primarily supportive, as the illness is self-limiting and typically resolves within 24 hours 1. It is essential to stay hydrated with clear fluids, such as water, diluted fruit juices, or oral rehydration solutions. Over-the-counter medications like loperamide (Imodium) can help control diarrhea in adults, but should be avoided if there's fever or bloody stool 1. Antibiotics are not recommended for uncomplicated cases.

The toxin produced by C. perfringens disrupts intestinal fluid balance, causing characteristic symptoms of abdominal cramps and diarrhea that typically begin 8-24 hours after consumption of contaminated food 1. It is crucial to seek medical attention if symptoms are severe, persist beyond 24 hours, or if you experience high fever, bloody stools, or signs of dehydration. Institutions, especially those with vulnerable populations, such as psychiatric hospitals, should ensure that precautions to prevent C. perfringens and other causes of foodborne illness are in place 1.

From the Research

Causes of Clostridium perfringens Food Poisoning

  • Clostridium perfringens is an important anaerobic pathogen causing food-borne gastrointestinal diseases in humans and animals 2.
  • Meat and meat products are the most common vehicles of C. perfringens type A food poisoning 2, 3.
  • Contamination of meat by the intestinal contents of slaughtered animals may serve as an important source of this pathogen to the food supply 2.
  • Other foods such as tuna can also be contaminated with C. perfringens, although they may have a low count of the bacteria 2.
  • Inadequately reheated foods, such as minced beef, can also cause outbreaks of C. perfringens food poisoning 3.

Prevention of Clostridium perfringens Food Poisoning

  • Effective bowel and nutrition policies are essential in preventing C. perfringens food poisoning 3.
  • Proper handling and cooking of foods can help prevent the contamination and growth of C. perfringens 4, 5.
  • Regular testing of foods for C. perfringens and its toxins can help identify contaminated foods and prevent outbreaks 2, 6.

Treatment of Clostridium perfringens Food Poisoning

  • C. perfringens food poisoning is typically self-limiting, and symptoms resolve on their own within a few days 5.
  • Treatment is usually focused on managing symptoms, such as diarrhea and abdominal cramps, and preventing dehydration 5.
  • In severe cases, hospitalization may be necessary to manage complications and prevent further dehydration 3.
  • Antibiotics may be prescribed in some cases, although their use is not always recommended due to the risk of antibiotic resistance 6.

Common Foods Causing Clostridium perfringens Food Poisoning

  • Meat and meat products, such as beef and chicken 2, 3.
  • Raw milk and dairy products 6.
  • Fish and seafood, such as tuna 2.
  • Other foods that are not properly handled or cooked, such as minced beef 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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