Does caffeine exacerbate symptoms of Restless Legs Syndrome (RLS)?

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Last updated: February 23, 2025View editorial policy

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From the Guidelines

Caffeine can exacerbate symptoms of Restless Legs Syndrome (RLS) and it is recommended to avoid or limit its intake, especially in the afternoon and evening. If you have RLS, it's generally recommended to avoid or limit caffeine intake, especially in the afternoon and evening, as it can increase symptoms of RLS for many people 1. This includes coffee, tea, cola, energy drinks, and chocolate. Some key points to consider:

  • Try cutting out caffeine completely for a few weeks to see if it improves your symptoms
  • Replace caffeinated beverages with water, herbal teas, or decaf options
  • If you do consume caffeine, limit it to mornings only and avoid it within 6 hours of bedtime Caffeine is a stimulant that can increase alertness and muscle activity, which may exacerbate the uncomfortable sensations and urge to move the legs, particularly when trying to rest or sleep, as suggested by the American Academy of Sleep Medicine clinical practice guideline 1. Additionally, maintaining good sleep hygiene, exercising regularly, and considering discussing medication options with your doctor if symptoms persist despite lifestyle changes can also help alleviate RLS symptoms. Some treatment options suggested by the American Academy of Sleep Medicine include the use of ferrous sulfate, dipyridamole, extended-release oxycodone, and bilateral high-frequency peroneal nerve stimulation, among others 1.

From the Research

Caffeine and Restless Legs Syndrome (RLS)

  • Caffeine may exacerbate symptoms of Restless Legs Syndrome (RLS), as reducing caffeine intake is recommended for managing RLS symptoms 2.
  • A clinical study found that caffeine is a major etiological factor in the causation of RLS, and that it can increase nervous system arousal and have a direct peripheral contractile effect on striated muscle, leading to RLS symptoms 3.
  • Another study suggested that the human body may produce a substance similar to caffeine in cases of iron deficiency and chronic renal failure, which could contribute to RLS symptoms 4.
  • While caffeine has been shown to have various benefits, such as improving exercise performance and cognitive function, its effects on RLS symptoms are not directly related to these benefits 5, 6.
  • Overall, the available evidence suggests that caffeine may worsen RLS symptoms, and reducing or avoiding caffeine intake may be beneficial for managing the condition 2, 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Restless legs, anxiety and caffeinism.

The Journal of clinical psychiatry, 1978

Research

International society of sports nutrition position stand: caffeine and exercise performance.

Journal of the International Society of Sports Nutrition, 2021

Research

Dietary sources, health benefits, and risks of caffeine.

Critical reviews in food science and nutrition, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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