ICD-10 Codes for Leukemia
The ICD-10-CM code for leukemia depends on the specific type and subtype of leukemia diagnosed. Leukemia is not a single disease but rather a heterogeneous group of hematologic malignancies, each with distinct ICD-10 codes based on the WHO classification system.
Primary Code Categories
The main ICD-10-CM codes for leukemia fall under the C91-C95 range:
Acute Myeloid Leukemia (AML)
- C92.0 - Acute myeloid leukemia (with various subtypes)
Chronic Myeloid Leukemia (CML)
- C92.1 - Chronic myeloid leukemia 3
- BCR-ABL1 positive chronic myelogenous leukemia
Acute Lymphoblastic Leukemia (ALL)
- C91.0 - Acute lymphoblastic leukemia
- Includes B-lymphoblastic leukemia and T-lymphoblastic leukemia 2
Chronic Lymphocytic Leukemia (CLL)
Other Specific Codes
- C92.4 - Acute promyelocytic leukemia (APL) with t(15;17)
- C93.0 - Acute monocytic/monoblastic leukemia
- C94.0 - Acute erythroid leukemia
- C94.2 - Acute megakaryoblastic leukemia
Important Coding Considerations
Each primary code requires a 5th digit to specify disease phase or remission status:
- .0 - Not having achieved remission (active disease)
- .1 - In remission
- .2 - In relapse
For example:
- C92.00 = Acute myeloid leukemia, not having achieved remission
- C92.01 = Acute myeloid leukemia, in remission
- C92.02 = Acute myeloid leukemia, in relapse
Special Populations
For pediatric cases and specific genetic subtypes, additional specificity may be required based on:
- Recurrent genetic abnormalities (t(8;21), inv(16), t(15;17), etc.) 1, 2, 1
- Myelodysplasia-related changes
- Therapy-related disease
- Down syndrome-associated leukemia 1
Mixed Phenotype Acute Leukemia (MPAL)
- C95.0 - Acute leukemia of ambiguous lineage
- Used for MPAL with various genetic abnormalities 1
The specific ICD-10 code must align with the WHO classification subtype determined through comprehensive diagnostic workup including morphology, immunophenotyping, cytogenetics, and molecular studies 1, 2, 6.