From the FDA Drug Label
The dosage of Sodium Chloride Oral Solution 23.4% is predicated on the specific requirements of the patient based on clinical and laboratory information. Ages 9 to 50 4 ml (equivalent to 936 mg) Children under 9 years and adults over 50 years Consult a physician
The recommended dosage and administration of sodium chloride tablets for patients requiring sodium replenishment is not directly stated in the provided drug label, as it refers to an oral solution. However, for the oral solution, the dosage is predicated on the specific requirements of the patient. For patients aged 9 to 50, the dosage is 4 ml (equivalent to 936 mg). For children under 9 years and adults over 50 years, it is recommended to consult a physician 1.
From the Research
The recommended dosage of sodium chloride tablets for patients requiring sodium replenishment is typically 1-2 grams (17-34 mEq) taken orally three to four times daily with a full glass of water, as supported by the most recent and highest quality study 2. This dosage may be adjusted based on the severity of sodium depletion, with a maximum daily dose generally not exceeding 8-12 grams. Administration should occur with meals to minimize gastrointestinal irritation.
- Patients should be monitored regularly through serum electrolyte measurements to ensure sodium levels return to the normal range of 135-145 mEq/L.
- Adequate fluid intake is essential during supplementation to prevent hypernatremia.
- The tablets work by directly increasing sodium levels in the body, which is crucial for maintaining proper fluid balance, nerve impulse transmission, and muscle function.
- Patients with heart failure, kidney disease, or hypertension require careful monitoring during sodium supplementation as excessive intake can worsen these conditions. Key considerations in managing sodium disorders include:
- Identifying the underlying cause of hyponatremia or hypernatremia, such as certain medications, excessive alcohol consumption, very low-salt diets, or excessive free water intake during exercise 3.
- Treating hypovolemic hyponatremia with normal saline infusions, euvolemic hyponatremia with restricting free water consumption or using salt tablets or intravenous vaptans, and hypervolemic hyponatremia by managing the underlying cause and free water restriction 3.
- Correcting the underlying cause and fluid deficit in hypernatremia, with hypotonic fluid replacement necessary in severe cases 3. Treatment duration varies depending on the underlying cause of hyponatremia but typically continues until normal sodium levels are achieved and stabilized, with gradual correction and clinical evaluation preferable over rapid normalization of sodium levels 2.