Is vellus hair considered true pubic hair, which develops under the influence of androgens during puberty?

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Velusna dlakavost NIJE prava pubična dlakavost

Ne, velusna dlakavost se ne smatra pravom pubičnom dlakavošću jer prava seksualna dlaka nastaje isključivo pod uticajem androgenih hormona koji transformišu velusne folikule u terminalne folikule. 1

Ključna razlika između velusne i terminalne dlake

Velusne dlake su:

  • Male, tanke (< 0.03 mm u prečniku)
  • Svetle, praktično nevidljive
  • Bez priloženog arrector pili mišića
  • Prisutne pre puberteta na celom telu 2

Terminalne dlake (prava pubična/seksualna dlaka) su:

  • Veće, deblje, tamnije
  • Pigmentirane
  • Nastaju transformacijom velusnih folikula pod dejstvom androgena 1

Mehanizam hormonske transformacije

Rast seksualne dlake je u potpunosti zavisan od prisustva androgena 1. Androgeni (testosteron i dihidrotestosteron) deluju na sledeći način:

  • Vezuju se za intracelularne androgene receptore u dermalnim papilama folikula
  • Indukuju transformaciju velusnih folikula u terminalne folikule u polno-specifičnim oblastima
  • Testosteron se konvertuje u dihidrotestosteron pomoću 5α-reduktaze 1
  • Ciklus rasta dlake traje oko 4 meseca za facijalnu dlaku 1

Klinička implikacija

Tokom puberteta, androgeni stimulišu razvoj:

  • Aksilarne dlake
  • Pubične dlake
  • Kod muškaraca: brade i druge sekundarne seksualne karakteristike 3

Bez androgena nema transformacije velusnih u terminalne folikule - što znači da velusna dlaka ostaje velusna i ne postaje prava seksualna/pubična dlaka 1, 4.

Važna napomena

Odnos terminal:velusna dlaka kod normalnih osoba je 7:1, dok kod patoloških stanja (npr. hirzutizam) ovaj odnos pada ispod 3:1 2. Ovo potvrđuje da je prisustvo terminalnih (ne velusnih) dlaka ono što definiše pravu hormonski-zavisnu dlakavost.

References

3
Research

Androgens and hair growth.

Dermatologic therapy, 2008

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