Differential Diagnosis for Uncircumcised Penis with Swelling of the Gland and Band of Connective Tissue

• Single Most Likely Diagnosis
  • Phimosis: This condition is characterized by the inability to retract the foreskin over the glans penis, which can lead to swelling and the formation of a tight band of connective tissue. It is a common issue in uncircumcised males and fits the described symptoms closely.
• Other Likely Diagnoses
  • Balanitis: An inflammation of the glans penis, which can cause swelling and may be associated with a band of connective tissue if chronic. It's often seen in uncircumcised males due to poor hygiene.
  • Paraphimosis: A condition where the foreskin is retracted behind the glans and cannot be returned to its original position, leading to swelling and potentially a band of connective tissue forming due to chronic irritation.
• Do Not Miss Diagnoses
  • Malignancy (e.g., Squamous Cell Carcinoma): Although rare, penile cancer can present with swelling and changes in the skin or foreskin. It's crucial to consider this diagnosis to ensure early detection and treatment.
  • Gangrene: In severe cases of paraphimosis or other conditions leading to compromised blood flow, gangrene can occur, which is a medical emergency.
• Rare Diagnoses
  • Lichen Sclerosus: A chronic inflammatory skin condition that can affect the genital area, leading to scarring and potentially a band of connective tissue. It's less common but should be considered in cases where other diagnoses are ruled out.
  • Peyronie's Disease: Characterized by the formation of fibrous scar tissue inside the penis, leading to curved, painful erections. While it doesn't typically cause swelling of the gland or a band of connective tissue around the penis, it could be considered in a differential diagnosis for penile abnormalities.