From the FDA Drug Label
DOSAGE & ADMINISTRATION Usual Adult dose is one or two tablets taken once or twice a day with or without food or as prescribed by a physician. The recommended dosage for Nicotinamide Riboside (NR) supplements is one or two tablets taken once or twice a day.
- The dosage may be taken with or without food.
- It is also recommended to follow the dosage prescribed by a physician 1. There is no information about the recommended dosage for Nicotinamide Mononucleotide (NMN) supplements in the provided drug label.
From the Research
The recommended dosage for Nicotinamide Riboside (NR) supplements is 250-500 mg per day, while Nicotinamide Mononucleotide (NMN) is commonly taken at 250-1000 mg daily to increase NAD+ levels, as supported by the most recent study in 2024 2.
Key Considerations
- NAD+ precursors, such as NR and NMN, have been shown to be safe and effective in increasing NAD+ levels in humans, with potential benefits for various age-related diseases and conditions 3, 4, 5, 6, 2.
- The optimal dosage and duration of supplementation may vary depending on individual factors, such as age, health status, and specific health goals.
- It is essential to consult with a healthcare provider before starting any supplement regimen, especially for those with existing health conditions or taking medications.
Administration and Safety
- NR and NMN supplements can be taken in the morning with or without food, although some people may experience better absorption when taken on an empty stomach.
- Potential side effects may include mild nausea, fatigue, or headaches when first starting, but these are generally considered safe and well-tolerated 2.
- Consistency is key, as NAD+ levels decline naturally with age, and it may take 2-4 weeks of consistent supplementation to notice benefits such as improved energy levels or cognitive function.
Future Directions
- Further studies are needed to determine the efficacy of NAD+ precursors in humans and to optimize the effects of NAD+ supplementation 4, 5, 6.
- The identification of the contribution of the host-gut microbiota interactions to NR and NMN metabolism has added to the complexity of NAD+ metabolism, and further research is needed to understand these interactions 4.