What is the treatment for hand, foot, and mouth disease?

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Last updated: June 11, 2025View editorial policy

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From the Research

Hand, foot, and mouth disease typically requires only supportive care as it is a viral infection that usually resolves on its own within 7-10 days. Treatment focuses on managing symptoms and includes over-the-counter pain relievers such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin) to reduce fever and alleviate pain from mouth sores, as recommended by the most recent study 1. Dosing should follow package instructions based on age and weight. Avoid aspirin in children due to the risk of Reye's syndrome.

Some key points to consider in the treatment of hand, foot, and mouth disease include:

  • Maintaining hydration by offering cold, soft foods like yogurt, smoothies, or popsicles that won't irritate mouth sores, and encouraging fluid intake to prevent dehydration
  • Using saltwater rinses (1/2 teaspoon salt in 1 cup warm water) to soothe mouth sores
  • Getting plenty of rest to aid in recovery
  • Practicing good hygiene by washing hands frequently and avoiding close contact with others while contagious, typically during the first week of illness

It's also important to note that there is no specific antiviral medication or vaccine for hand, foot, and mouth disease, as the body's immune system will clear the infection naturally 2, 3, 4, 5. However, in severe or complicated cases, intravenous immunoglobulin may be considered as a treatment option, as recommended by several national and international guideline committees 1.

References

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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