Does pseudoexfoliation syndrome cause anisocytosis or reduce poikilocytosis?

From the Research

Pseudoexfoliation syndrome does not cause polymegathism or reduce pleomorphism in the context of red blood cell morphology, as these terms are not directly related to the ocular condition. Pseudoexfoliation syndrome is an age-related disorder characterized by the production and accumulation of abnormal fibrillar material in various ocular tissues, particularly the anterior segment of the eye. This condition primarily affects the lens, iris, and trabecular meshwork, leading to complications such as glaucoma, zonular weakness, and increased risk during cataract surgery. The pathophysiology involves the deposition of whitish, dandruff-like material on ocular structures, which can obstruct the trabecular meshwork and impair aqueous humor outflow, potentially increasing intraocular pressure. However, in the context of corneal alterations, pseudoexfoliation syndrome has been associated with endothelial cell anomalies, including polymegathism and pleomorphism, as observed in a study using in vivo corneal confocal microscopy 1. Key points to consider include:

• Pseudoexfoliation syndrome is a common cause of secondary open-angle glaucoma, which is more severe than primary open-angle glaucoma 2.
• The syndrome is characterized by the presence of white material on the lens capsule and other anterior chamber components, and can be associated with systemic alterations in the extracellular matrix of various tissues 2.
• The relationship between pseudoexfoliation syndrome and polymegathism or pleomorphism is limited to the context of corneal endothelial cell morphology, and not related to red blood cell morphology 1. In summary, pseudoexfoliation syndrome is an ocular condition that can cause endothelial cell anomalies, including polymegathism and pleomorphism, in the context of corneal alterations, but is not directly related to red blood cell morphology. Further research is needed to fully understand the clinical characteristics and systemic associations of pseudoexfoliation syndrome, as well as its relationship to other ocular and systemic conditions 3, 2.