From the Research
Pseudoexfoliation syndrome causes corneal thinning through the abnormal production and accumulation of extracellular fibrillar material, which disrupts the normal corneal architecture and interferes with endothelial cell function, as supported by the most recent study 1. The condition primarily affects the anterior segment of the eye, where fibrillar material deposits on various ocular structures including the cornea.
- The thinning occurs because pseudoexfoliation material accumulates on and between endothelial cells, leading to cell loss and dysfunction.
- The corneal endothelium, which maintains corneal clarity and thickness through its pump function, becomes compromised.
- Additionally, the syndrome causes increased oxidative stress and inflammation in the anterior chamber, which further damages corneal tissue.
- The abnormal extracellular matrix metabolism associated with pseudoexfoliation syndrome also affects corneal collagen and proteoglycan organization, weakening the structural integrity of the cornea. These combined effects result in progressive corneal thinning, which can impact visual acuity and increase the risk of corneal decompensation, particularly after intraocular surgery, as noted in a study from 2. However, it's essential to consider the most recent and highest-quality evidence when making clinical decisions, and in this case, the study from 1 provides valuable insights into the mechanisms of pseudoexfoliation syndrome and its effects on the cornea. The other studies, such as 3, 4, and 5, provide additional information on the management and clinical presentation of pseudoexfoliation glaucoma, but they do not directly address the question of how pseudoexfoliation syndrome causes corneal thinning. Therefore, the recommendation is based on the most relevant and recent study 1.