Is chasteberry (Vitex agnus-castus) safe to use for premenstrual syndrome (PMS) symptoms?

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Last updated: June 13, 2025View editorial policy

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From the Research

Chasteberry (Vitex agnus-castus) is generally considered safe for most women to use for PMS symptoms, but it should be used with caution and preferably under healthcare supervision. The most recent and highest quality study, a systematic review and meta-analysis published in 2017 1, found that Vitex agnus castus preparations have a large pooled effect in reducing PMS symptoms, although the study noted high heterogeneity and risk of publication bias. Typical dosages range from 20-40 mg of dried fruit extract daily, taken for at least three menstrual cycles to evaluate effectiveness.

Side Effects and Interactions

Side effects are usually mild and can include:

  • Gastrointestinal discomfort
  • Headache
  • Itching
  • Rash
  • Menstrual changes Chasteberry works by affecting hormone levels, particularly by reducing prolactin and balancing estrogen and progesterone, which may help alleviate symptoms like breast tenderness, irritability, and mood swings. However, women who are pregnant, breastfeeding, have hormone-sensitive conditions (like breast cancer), or are taking hormonal medications (including birth control pills and hormone replacement therapy) should avoid chasteberry due to potential interactions.

Precautions and Contraindications

Additionally, it may interact with dopamine-related medications and certain antipsychotics. Always inform your healthcare provider before starting chasteberry, especially if you have existing medical conditions or take other medications. Other studies, such as those published in 2005 2 and 2013 3, also support the safety and efficacy of chasteberry for PMS symptoms, but the 2017 study 1 provides the most recent and comprehensive evidence.

Key Points to Consider

  • Chasteberry may be beneficial for PMS symptoms, but its use should be individualized and monitored by a healthcare provider.
  • The herb may interact with certain medications, including hormonal therapies and dopamine-related drugs.
  • Women with hormone-sensitive conditions or those who are pregnant or breastfeeding should avoid using chasteberry.
  • Further research is needed to fully understand the effects and potential interactions of chasteberry, as noted in studies such as those published in 2003 4 and 2017 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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