From the Guidelines
Medications that can increase metabolic rate include GLP-1 receptor agonists like semaglutide and liraglutide, as well as phentermine and phentermine/topiramate, which are primarily indicated for obesity management. These medications can increase metabolic rate by activating the sympathetic nervous system, suppressing appetite, and delaying gastric emptying 1.
- GLP-1 receptor agonists like semaglutide and liraglutide may indirectly affect metabolism while primarily working through appetite suppression, with semaglutide 2.4 mg demonstrating cardiovascular benefits in persons with obesity 1.
- Phentermine (typical dose 15-37.5mg daily) increases metabolism by activating the sympathetic nervous system, though it's primarily indicated for obesity, not metabolic enhancement 1.
- Phentermine/topiramate is a combination medication that can increase metabolic rate, but its use is less robust than that of GLP-1 RA–based agents, and it's associated with increased heart rate and risk of mood and sleep disorders 1.
- Other medications like orlistat, lorcaserin, and bupropion/naltrexone can also increase metabolic rate, but their effects are often modest and may be associated with significant side effects 1. It's essential to note that these medications should only be used under medical supervision for specific conditions, as they carry significant side effects, and lifestyle changes like exercise and proper nutrition remain the safest and most sustainable approaches to managing metabolic health 1.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Medications that Increase Metabolic Rate
Several medications can increase metabolic rate, including:
- Levothyroxine, a thyroid hormone replacement therapy, which can increase metabolic rate in individuals with hypothyroidism 2
- Certain anti-obesity medications, such as sibutramine and orlistat, which can increase energy expenditure and enhance weight loss 3
- Stimulants, such as amphetamine and caffeine, which can increase alertness, energy, and metabolic rate by acting on adrenergic, dopaminergic, and serotonergic pathways 4, 5
Mechanisms of Action
These medications can increase metabolic rate through various mechanisms, including:
- Increasing the levels of certain neurotransmitters, such as dopamine and norepinephrine, which can enhance motivation and energy expenditure 4, 5
- Inhibiting the reuptake of neurotransmitters, such as serotonin, which can increase feelings of fullness and reduce appetite 3, 5
- Enhancing the activity of the thyroid hormone, which can increase metabolic rate and energy expenditure 2, 6
Interactions and Precautions
It is essential to note that these medications can interact with other substances, such as food, dietary supplements, and other medications, which can affect their absorption and efficacy 2, 6. For example: