From the Guidelines
No, exceeding the maximum recommended dose of 70mg of Vyvanse (lisdexamfetamine) per day is not advised. According to the most recent and highest quality study, the maximum daily dose of Vyvanse is 70mg, and increasing this dose may lead to serious side effects, including cardiovascular problems and severe psychiatric effects 1. The study highlights that the usual starting dose of lisdexamfetamine is 20-30 mg, and titration should not exceed 10 mg weekly to a maximum of 70 mg daily.
Key Considerations
- The FDA-approved maximum daily dose for Vyvanse is 70mg for both adults and children with ADHD, and for adults with moderate to severe binge eating disorder.
- Taking higher doses increases the risk of serious side effects, including:
- Cardiovascular problems (increased blood pressure, heart rate, risk of stroke or heart attack)
- Severe psychiatric effects (psychosis, mania)
- Heightened potential for dependence or addiction
- Vyvanse works by being converted in the body to dextroamphetamine, which affects neurotransmitters in the brain, and has a long duration of action (10-14 hours), making higher doses unnecessary for coverage throughout the day.
Recommendations
- If someone feels their current dose is ineffective, they should consult their healthcare provider rather than increasing the dose themselves.
- Only a healthcare provider can determine if a different medication or treatment approach would be more appropriate based on individual needs and medical history, as seen in the study published in the American Journal of Obstetrics and Gynecology 1.
From the Research
Dosage of Vyvanse (Lisdexamfetamine)
- The maximum daily dose of Vyvanse (lisdexamfetamine) is 70mg, as indicated in the study 2.
- In the study 3, patients were treated with lisdexamfetamine up to 70 mg/day, and the results showed significant reductions in ADHD symptoms.
- Another study 4 compared the efficacy of lisdexamfetamine with other medications, including mixed amphetamine salts and methylphenidate, and found that lisdexamfetamine had a high effect size in reducing ADHD symptoms.
- However, there is no evidence to suggest that taking more than 70mg of Vyvanse per day is safe or effective, and it is not recommended to exceed the maximum daily dose without consulting a healthcare professional.
Safety and Efficacy
- The study 2 found that lisdexamfetamine was generally well-tolerated, with common adverse events including decreased appetite, decreased weight, insomnia, and dry mouth.
- The study 5 found that lisdexamfetamine had a statistically significant better probability of response compared to other medications, including methylphenidate and atomoxetine.
- However, the study 6 found that the use of certain psychiatric medications, including anxiolytics and antidepressants, was associated with a higher risk of amyotrophic lateral sclerosis (ALS), although this study did not specifically investigate the use of lisdexamfetamine.
Conclusion is not allowed, and the response should continue with more subheadings and bullet points if necessary.
Additional Information
- It is essential to follow the recommended dosage and consult a healthcare professional before taking any medication, including Vyvanse.
- The studies 2, 3, 4, and 5 provide evidence for the efficacy and safety of lisdexamfetamine in the treatment of ADHD, but more research is needed to fully understand its effects and potential interactions with other medications.
- Patients should be monitored closely for adverse events and changes in their condition, and the dosage should be adjusted accordingly, as indicated in the studies 2 and 3.