Is Xeroform (petrolatum impregnated gauze) recommended for dressing changes?

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Last updated: June 15, 2025View editorial policy

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From the Guidelines

Xeroform (petrolatum impregnated gauze) is not the preferred choice for dressing changes due to its dry nature and lack of evidence supporting its use over wet dressings, such as honey or silver sulfadiazine-impregnated gauze dressings, which have shown benefits in reducing infection and promoting healing 1.

Key Considerations

  • The evidence suggests that wet dressings, such as those impregnated with honey or silver sulfadiazine, may be more effective in reducing infection and promoting healing compared to dry dressings like Xeroform 1.
  • Xeroform, a petrolatum gauze dressing, was found to have no statistically significant difference in infection rate compared to wet dressings in a non-RCT study with very-low-quality evidence 1.
  • The use of Xeroform may be considered in specific situations where a dry dressing is preferred, but its limitations and potential drawbacks should be weighed against the benefits of wet dressings.

Clinical Implications

  • When selecting a dressing for wound care, consideration should be given to the type of wound, the level of exudate, and the patient's individual needs.
  • Wet dressings, such as those containing honey or silver sulfadiazine, may be preferred for their antimicrobial properties and ability to promote a moist wound environment, which can enhance healing 1.
  • However, the choice of dressing ultimately depends on the specific clinical context and the availability of high-quality evidence to support its use.

From the Research

Xeroform Gaze for Dressing Changes

  • Xeroform is a petrolatum impregnated gauze, and its use in dressing changes has been studied in various contexts.
  • According to a study published in 2000 2, petrolatum emulsion dressings like Xeroform were compared with other non-adherent dressings for hand surgery wounds, and the results showed that petrolatum emulsion dressings were easier to remove, required less soaking, and were less painful to remove.
  • However, the study also noted that Xeroform was more difficult to apply than other dressings.
  • Another study published in 2009 3 discussed the use of Mepitel, a non-adherent wound dressing with Safetac technology, which is also designed for atraumatic and pain-free dressing changes.
  • While Xeroform is not explicitly mentioned in this study, it suggests that non-adherent dressings like Xeroform can be beneficial for wound care.
  • A more recent study published in 2021 4 emphasized the importance of maintaining a moist wound environment for optimal healing, but did not specifically discuss Xeroform.
  • Overall, the evidence suggests that Xeroform can be a suitable option for dressing changes, particularly for wounds that require a non-adherent dressing, but its use should be considered on a case-by-case basis.

Key Considerations

  • Ease of application and removal
  • Pain associated with dressing changes
  • Wound maceration and trauma
  • Cost-effectiveness
  • Specific wound types and skin injuries

Relevant Studies

  • 2: A comparison of three primary non-adherent dressings applied to hand surgery wounds.
  • 3: Mepitel: a non-adherent wound dressing with Safetac technology.
  • 4: Moist Wound Healing with Commonly Available Dressings.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Mepitel: a non-adherent wound dressing with Safetac technology.

British journal of nursing (Mark Allen Publishing), 2009

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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